Organic anion transporter 3 (SLC22A8)

About Organic anion transporter 3

Organic anion transporter 3 (SLC22A8) is a protein from Homo sapiens identified by UniProt accession Q8TCC7, 542 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.

Target properties

Protein name	Organic anion transporter 3
UniProt accession	Q8TCC7
Gene	SLC22A8
Organism	Homo sapiens
Length	542 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (5)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (114)

Diseases linked to this target (Open Targets).

gout · score 0.50
influenza · score 0.37
epilepsy · score 0.37
urinary tract infection · score 0.35
infection · score 0.27
obesity · score 0.27
male infertility · score 0.26
cystitis · score 0.26
neurodegenerative disease · score 0.23
pentosuria · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TCC7-F1	alphafold	PREDICTED	86.05	—

Amino-acid sequence (542 residues)

MTFSEILDRV GSMGHFQFLH VAILGLPILN MANHNLLQIF TAATPVHHCR PPHNASTGPW VLPMGPNGKP ERCLRFVHPP NASLPNDTQR AMEPCLDGWV YNSTKDSIVT EWDLVCNSNK LKEMAQSIFM AGILIGGLVL GDLSDRFGRR PILTCSYLLL AASGSGAAFS PTFPIYMVFR FLCGFGISGI TLSTVILNVE WVPTRMRAIM STALGYCYTF GQFILPGLAY AIPQWRWLQL TVSIPFFVFF LSSWWTPESI RWLVLSGKSS KALKILRRVA VFNGKKEEGE RLSLEELKLN LQKEISLAKA KYTASDLFRI PMLRRMTFCL SLAWFATGFA YYSLAMGVEE FGVNLYILQI IFGGVDVPAK FITILSLSYL GRHTTQAAAL LLAGGAILAL TFVPLDLQTV RTVLAVFGKG CLSSSFSCLF LYTSELYPTV IRQTGMGVSN LWTRVGSMVS PLVKITGEVQ PFIPNIIYGI TALLGGSAAL FLPETLNQPL PETIEDLENW SLRAKKPKQE PEVEKASQRI PLQPHGPGLG SS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards