Solute carrier family 22 member 6 (SLC22A6)

About Solute carrier family 22 member 6

Solute carrier family 22 member 6 (SLC22A6) is a protein from Homo sapiens identified by UniProt accession Q4U2R8, 563 residues long. MolForge cross-references it against 6 known binders and 90 disease associations.

Target properties

Protein name	Solute carrier family 22 member 6
UniProt accession	Q4U2R8
Gene	SLC22A6
Organism	Homo sapiens
Length	563 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). Approved drug exists

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs acting on this target (3)

Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.

Disease associations (90)

Diseases linked to this target (Open Targets).

gout · score 0.50
influenza · score 0.37
epilepsy · score 0.37
urinary tract infection · score 0.35
urate measurement · score 0.33
obesity · score 0.27
infection · score 0.27
male infertility · score 0.26
cystitis · score 0.26
neuroinflammatory disorder · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q4U2R8-F1	alphafold	PREDICTED	83.05	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q4U2R8.

Amino-acid sequence (563 residues)

MAFNDLLQQV GGVGRFQQIQ VTLVVLPLLL MASHNTLQNF TAAIPTHHCR PPADANLSKN GGLEVWLPRD RQGQPESCLR FTSPQWGLPF LNGTEANGTG ATEPCTDGWI YDNSTFPSTI VTEWDLVCSH RALRQLAQSL YMVGVLLGAM VFGYLADRLG RRKVLILNYL QTAVSGTCAA FAPNFPIYCA FRLLSGMALA GISLNCMTLN VEWMPIHTRA CVGTLIGYVY SLGQFLLAGV AYAVPHWRHL QLLVSAPFFA FFIYSWFFIE SARWHSSSGR LDLTLRALQR VARINGKREE GAKLSMEVLR ASLQKELTMG KGQASAMELL RCPTLRHLFL CLSMLWFATS FAYYGLVMDL QGFGVSIYLI QVIFGAVDLP AKLVGFLVIN SLGRRPAQMA ALLLAGICIL LNGVIPQDQS IVRTSLAVLG KGCLAASFNC IFLYTGELYP TMIRQTGMGM GSTMARVGSI VSPLVSMTAE LYPSMPLFIY GAVPVAASAV TVLLPETLGQ PLPDTVQDLE SRWAPTQKEA GIYPRKGKQT RQQQEHQKYM VPLQASAQEK NGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards