Aldo-keto reductase family 1 member C1 (AKR1C1)

About Aldo-keto reductase family 1 member C1

Aldo-keto reductase family 1 member C1 (AKR1C1) is a protein from Homo sapiens identified by UniProt accession Q04828, 323 residues long. MolForge cross-references it against 0 known binders and 151 disease associations.

Target properties

Protein name	Aldo-keto reductase family 1 member C1
UniProt accession	Q04828
Gene	AKR1C1
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (7)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (151)

Diseases linked to this target (Open Targets).

BMI-adjusted waist-hip ratio · score 0.36
lean body mass · score 0.35
waist-hip ratio · score 0.34
body height · score 0.34
BMI-adjusted waist circumference · score 0.30
appendicular lean mass · score 0.28
peak expiratory flow · score 0.28
fat body mass · score 0.27
ovarian cancer · score 0.25
BMI-adjusted hip circumference · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q04828-F1	alphafold	PREDICTED	97.59	—

Amino-acid sequence (323 residues)

MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA VEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN RNVRYLTLDI FAGPPNYPFS DEY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards