About 3',5'-cyclic-AMP phosphodiesterase 4A
3',5'-cyclic-AMP phosphodiesterase 4A (PDE4A) is a protein
from Homo sapiens identified by UniProt accession
P27815, 886 residues long.
MolForge cross-references it against 0 known binders and
503 disease associations.
Target properties
| Protein name | 3',5'-cyclic-AMP phosphodiesterase 4A |
|---|
| UniProt accession | P27815 |
|---|
| Gene | PDE4A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 886 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (15)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (503)
Diseases linked to this target (Open Targets).
- psoriasis · score 0.66
- chronic obstructive pulmonary disease · score 0.61
- asthma · score 0.60
- Airway obstruction · score 0.58
- atopic eczema · score 0.58
- psoriatic arthritis · score 0.57
- coronary artery disease · score 0.55
- stroke · score 0.55
- chronic bronchitis · score 0.54
- chronic kidney disease · score 0.54
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P27815-F1 | alphafold | PREDICTED | 64.50 | — |
Amino-acid sequence (886 residues)
MEPPTVPSER SLSLSLPGPR EGQATLKPPP QHLWRQPRTP IRIQQRGYSD SAERAERERQ PHRPIERADA MDTSDRPGLR TTRMSWPSSF HGTGTGSGGA GGGSSRRFEA ENGPTPSPGR SPLDSQASPG LVLHAGAATS QRRESFLYRS DSDYDMSPKT MSRNSSVTSE AHAEDLIVTP FAQVLASLRS VRSNFSLLTN VPVPSNKRSP LGGPTPVCKA TLSEETCQQL ARETLEELDW CLEQLETMQT YRSVSEMASH KFKRMLNREL THLSEMSRSG NQVSEYISTT FLDKQNEVEI PSPTMKEREK QQAPRPRPSQ PPPPPVPHLQ PMSQITGLKK LMHSNSLNNS NIPRFGVKTD QEELLAQELE NLNKWGLNIF CVSDYAGGRS LTCIMYMIFQ ERDLLKKFRI PVDTMVTYML TLEDHYHADV AYHNSLHAAD VLQSTHVLLA TPALDAVFTD LEILAALFAA AIHDVDHPGV SNQFLINTNS ELALMYNDES VLENHHLAVG FKLLQEDNCD IFQNLSKRQR QSLRKMVIDM VLATDMSKHM TLLADLKTMV ETKKVTSSGV LLLDNYSDRI QVLRNMVHCA DLSNPTKPLE LYRQWTDRIM AEFFQQGDRE RERGMEISPM CDKHTASVEK SQVGFIDYIV HPLWETWADL VHPDAQEILD TLEDNRDWYY SAIRQSPSPP PEEESRGPGH PPLPDKFQFE LTLEEEEEEE ISMAQIPCTA QEALTAQGLS GVEEALDATI AWEASPAQES LEVMAQEASL EAELEAVYLT QQAQSTGSAP VAPDEFSSRE EFVVAVSHSS PSALALQSPL LPAWRTLSVS EHAPGLPGLP STAAEVEAQR EHQAAKRACS ACAGTFGEDT SALPAPGGGG SGGDPT
Explore 3',5'-cyclic-AMP phosphodiesterase 4A with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets