About Protein phosphatase EYA3
Protein phosphatase EYA3 (EYA3) is a protein
from Homo sapiens identified by UniProt accession
Q99504, 573 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | Protein phosphatase EYA3 |
|---|
| UniProt accession | Q99504 |
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| Gene | EYA3 |
|---|
| Organism | Homo sapiens |
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| Length | 573 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (80)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.27
- low grade glioma · score 0.26
- breast adenocarcinoma · score 0.26
- ovarian cancer · score 0.25
- smoking status measurement · score 0.25
- esophageal cancer · score 0.24
- head and neck squamous cell carcinoma · score 0.23
- squamous cell lung carcinoma · score 0.23
- lung adenocarcinoma · score 0.23
- total cholesterol measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99504-F1 | alphafold | PREDICTED | 65.16 | — |
Amino-acid sequence (573 residues)
MEEEQDLPEQ PVKKAKMQES GEQTISQVSN PDVSDQKPET SSLASNLPMS EEIMTCTDYI PRSSNDYTSQ MYSAKPYAHI LSVPVSETAY PGQTQYQTLQ QTQPYAVYPQ ATQTYGLPPF GALWPGMKPE SGLIQTPSPS QHSVLTCTTG LTTSQPSPAH YSYPIQASST NASLISTSST IANIPAAAVA SISNQDYPTY TILGQNQYQA CYPSSSFGVT GQTNSDAEST TLAATTYQSE KPSVMAPAPA AQRLSSGDPS TSPSLSQTTP SKDTDDQSRK NMTSKNRGKR KADATSSQDS ELERVFLWDL DETIIIFHSL LTGSYAQKYG KDPTVVIGSG LTMEEMIFEV ADTHLFFNDL EECDQVHVED VASDDNGQDL SNYSFSTDGF SGSGGSGSHG SSVGVQGGVD WMRKLAFRYR KVREIYDKHK SNVGGLLSPQ RKEALQRLRA EIEVLTDSWL GTALKSLLLI QSRKNCVNVL ITTTQLVPAL AKVLLYGLGE IFPIENIYSA TKIGKESCFE RIVSRFGKKV TYVVIGDGRD EEIAAKQHNM PFWRITNHGD LVSLHQALEL DFL
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