About Thyroid hormone receptor beta
Thyroid hormone receptor beta (THRB) is a protein
from Homo sapiens identified by UniProt accession
P10828, 461 residues long.
MolForge cross-references it against 0 known binders and
504 disease associations.
Target properties
| Protein name | Thyroid hormone receptor beta |
|---|
| UniProt accession | P10828 |
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| Gene | THRB |
|---|
| Organism | Homo sapiens |
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| Length | 461 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (504)
Diseases linked to this target (Open Targets).
- selective pituitary resistance to thyroid hormone · score 0.75
- generalized resistance to thyroid hormone · score 0.70
- glycogen storage disease due to glycogen branching enzyme deficiency · score 0.69
- thyroid hormone resistance syndrome · score 0.62
- hypothyroidism · score 0.61
- differentiated thyroid carcinoma · score 0.55
- congenital hypothyroidism · score 0.55
- depressive disorder · score 0.54
- myxedema · score 0.53
- thyroid cancer · score 0.50
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10828-F1 | alphafold | PREDICTED | 80.21 | — |
Amino-acid sequence (461 residues)
MTPNSMTENG LTAWDKPKHC PDREHDWKLV GMSEACLHRK SHSERRSTLK NEQSSPHLIQ TTWTSSIFHL DHDDVNDQSV SSAQTFQTEE KKCKGYIPSY LDKDELCVVC GDKATGYHYR CITCEGCKGF FRRTIQKNLH PSYSCKYEGK CVIDKVTRNQ CQECRFKKCI YVGMATDLVL DDSKRLAKRK LIEENREKRR REELQKSIGH KPEPTDEEWE LIKTVTEAHV ATNAQGSHWK QKRKFLPEDI GQAPIVNAPE GGKVDLEAFS HFTKIITPAI TRVVDFAKKL PMFCELPCED QIILLKGCCM EIMSLRAAVR YDPESETLTL NGEMAVTRGQ LKNGGLGVVS DAIFDLGMSL SSFNLDDTEV ALLQAVLLMS SDRPGLACVE RIEKYQDSFL LAFEHYINYR KHHVTHFWPK LLMKVTDLRM IGACHASRFL HMKVECPTEL FPPLFLEVFE D
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