Roxadustat

BLOOD AND BLOOD FORMING ORGANS

Key facts

Roxadustat is a drug catalogued in DrugCentral. It was first approved by the PMDA in 2019. DrugCentral lists 9 molecular targets, including THRB, THRA and A085R. Recorded indications include Anemia in chronic kidney disease and Refractory anemia (clinical).

• Molecular targets: THRB, THRA, A085R and EGLN2 (9 listed in DrugCentral).
• Indications: Anemia in chronic kidney disease and Refractory anemia (clinical).
• ATC code: B03XA05 (Other antianemic preparations).
• Molecular formula: C19H16N2O5; molecular weight 352.35 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Anemia in chronic kidney disease
• Refractory anemia (clinical)

Mechanism & targets

Molecular targets (9)

Target	Gene	Action	Activity
Thyroid hormone receptor beta	THRB	unknown	EC50 7.89
Thyroid hormone receptor alpha	THRA	unknown	EC50 7.49
Prolyl 4-hydroxylase	A085R	unknown	Ki 5.97
Egl nine homolog 2	EGLN2	inhibitor	IC50 5.24
Egl nine homolog 3	EGLN3	inhibitor	IC50 5.18
Gamma-butyrobetaine dioxygenase	BBOX1	unknown	IC50 5.09
Alpha-ketoglutarate-dependent dioxygenase FTO	FTO	unknown	IC50 5.01
Aspartyl/asparaginyl beta-hydroxylase	ASPH	unknown	IC50 4.71
Egl nine homolog 1	EGLN1	inhibitor	IC50 4.54

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2021-08-18	EMA	—	ASTELLAS PHARMA EUROPE B.V.
2019-09-20	PMDA	—	Astellas Pharma Inc.

ATC classification

ATC code	Therapeutic hierarchy
B03XA05	BLOOD AND BLOOD FORMING ORGANS › ANTIANEMIC PREPARATIONS › OTHER ANTIANEMIC PREPARATIONS › Other antianemic preparations

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Roxadustat is on its molecule page.

• Molecular formula: C₁₉H₁₆N₂O₅
• Molecular weight: 352.35 g/mol
• CAS number: —
• InChIKey: YOZBGTLTNGAVFU-UHFFFAOYSA-N
• PubChem CID: 11256664

CC1=C2C=C(OC3=CC=CC=C3)C=CC2=C(O)C(=N1)C(=O)NCC(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Roxadustat used for?

DrugCentral lists the following indications for Roxadustat: Anemia in chronic kidney disease and Refractory anemia (clinical).

How does Roxadustat work?

Its molecular targets in DrugCentral include THRB, THRA, A085R and EGLN2 (inhibitor).

When was Roxadustat first approved?

Roxadustat was first approved by the PMDA in 2019.

What is the chemical formula of Roxadustat?

Roxadustat has the molecular formula C19H16N2O5 and a molecular weight of 352.35 g/mol.

Sources

• DrugCentral drug card 5371 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2338329 — compound record and bioactivity
• PubChem CID 11256664 — chemical identifiers
• DrugBank DB04847 — drug record
• FDA UNII X3O30D9YMX — substance identity
• UniProt P10828 (THRB) — target protein
• UniProt P10827 (THRA) — target protein
• UniProt Q96KS0 (EGLN2) — target protein
• UniProt Q9H6Z9 (EGLN3) — target protein
• UniProt O75936 (BBOX1) — target protein
• UniProt Q9C0B1 (FTO) — target protein

How this page is built: methodology · editorial policy & corrections.