Alpha-ketoglutarate-dependent dioxygenase FTO (FTO)
Homo sapiens — UniProt Q9C0B1
Data last refreshed: (UniProt release unknown)
Key facts
Alpha-ketoglutarate-dependent dioxygenase FTO (FTO) is a protein from Homo sapiens identified by UniProt accession Q9C0B1, 505 residues long. MolForge cross-references it against 11 known binders and 619 disease associations.
- UniProt accession: Q9C0B1; gene symbol FTO.
- Organism: Homo sapiens.
- Length: 505 amino acids.
- Top disease associations (Open Targets): lethal polymalformative syndrome, Boissel type, obesity and type 2 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Alpha-ketoglutarate-dependent dioxygenase FTO |
|---|---|
| UniProt accession | Q9C0B1 |
| Gene | FTO |
| Organism | Homo sapiens |
| Length | 505 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (619)
Diseases linked to this target (Open Targets).
- lethal polymalformative syndrome, Boissel type · score 0.72
- obesity · score 0.53
- type 2 diabetes mellitus · score 0.47
- body mass index · score 0.45
- lean body mass · score 0.44
- body fat percentage · score 0.44
- fat body mass · score 0.43
- body weight · score 0.42
- high density lipoprotein cholesterol measurement · score 0.42
- waist circumference · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9C0B1-F1 | alphafold | PREDICTED | 91.00 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9C0B1.
Amino-acid sequence (505 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FTO?
The strongest Open Targets associations for FTO are lethal polymalformative syndrome, Boissel type, obesity, type 2 diabetes mellitus, body mass index and lean body mass.
How long is the FTO protein?
The Homo sapiens FTO protein (UniProt Q9C0B1) is 505 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9C0B1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9C0B1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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