About Thyroid hormone receptor alpha
Thyroid hormone receptor alpha (THRA) is a protein
from Homo sapiens identified by UniProt accession
P10827, 490 residues long.
MolForge cross-references it against 0 known binders and
586 disease associations.
Target properties
| Protein name | Thyroid hormone receptor alpha |
|---|
| UniProt accession | P10827 |
|---|
| Gene | THRA |
|---|
| Organism | Homo sapiens |
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| Length | 490 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (586)
Diseases linked to this target (Open Targets).
- hypothyroidism · score 0.61
- congenital hypothyroidism · score 0.56
- differentiated thyroid carcinoma · score 0.55
- depressive disorder · score 0.54
- myxedema · score 0.53
- peripheral resistance to thyroid hormones · score 0.52
- thyroid cancer · score 0.50
- thyroid carcinoma · score 0.46
- neurodegenerative disease · score 0.46
- nodular goiter · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10827-F1 | alphafold | PREDICTED | 73.05 | — |
Amino-acid sequence (490 residues)
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCSLKTSMS GYIPSYLDKD EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM IRSLQQRPEP TPEEWDLIHI ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE HYVNHRKHNI PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ QLLGMHVVQG PQVRQLEQQL GEAGSLQGPV LQHQSPKSPQ QRLLELLHRS GILHARAVCG EDDSSEADSP SSSEEEPEVC EDLAGNAASP
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