Molidustat

BLOOD AND BLOOD FORMING ORGANS

Key facts

Molidustat is a drug catalogued in DrugCentral. It was first approved by the PMDA in 2021. DrugCentral lists 5 molecular targets, including EGLN1, EGLN3 and EGLN2. Recorded indications include Renal anemia.

• Molecular targets: EGLN1, EGLN3, EGLN2 and A085R (5 listed in DrugCentral).
• Indications: Renal anemia.
• ATC code: B03XA09 (Other antianemic preparations).
• Molecular formula: C13H14N8O2; molecular weight 314.31 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Renal anemia

Mechanism & targets

Molecular targets (5)

Target	Gene	Action	Activity
Egl nine homolog 1	EGLN1	inhibitor	IC50 6.55
Egl nine homolog 3	EGLN3	inhibitor	IC50 6.35
Egl nine homolog 2	EGLN2	inhibitor	IC50 6.32
Prolyl 4-hydroxylase	A085R	unknown	Ki 4.79
Hypoxia-inducible factor 1-alpha inhibitor	HIF1AN	unknown	IC50 4.51

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2021-01-22	PMDA	—	BAYER YAKUHIN, Ltd

ATC classification

ATC code	Therapeutic hierarchy
B03XA09	BLOOD AND BLOOD FORMING ORGANS › ANTIANEMIC PREPARATIONS › OTHER ANTIANEMIC PREPARATIONS › Other antianemic preparations

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Molidustat is on its molecule page.

• Molecular formula: C₁₃H₁₄N₈O₂
• Molecular weight: 314.31 g/mol
• CAS number: 1154028-82-6
• InChIKey: IJMBOKOTALXLKS-UHFFFAOYSA-N
• PubChem CID: 59603622

C1COCCN1C2=NC=NC(=C2)N3C(=O)C(=CN3)N4C=CN=N4

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Molidustat used for?

DrugCentral lists the following indications for Molidustat: Renal anemia.

How does Molidustat work?

Its molecular targets in DrugCentral include EGLN1 (inhibitor), EGLN3 (inhibitor), EGLN2 (inhibitor) and A085R.

When was Molidustat first approved?

Molidustat was first approved by the PMDA in 2021.

What is the chemical formula of Molidustat?

Molidustat has the molecular formula C13H14N8O2 and a molecular weight of 314.31 g/mol.

Sources

• DrugCentral drug card 5486 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3646118 — compound record and bioactivity
• PubChem CID 59603622 — chemical identifiers
• DrugBank DB15642 — drug record
• FDA UNII 9JH486CZ13 — substance identity
• UniProt Q9GZT9 (EGLN1) — target protein
• UniProt Q9H6Z9 (EGLN3) — target protein
• UniProt Q96KS0 (EGLN2) — target protein
• UniProt Q9NWT6 (HIF1AN) — target protein

How this page is built: methodology · editorial policy & corrections.