About Prolyl hydroxylase EGLN2
Prolyl hydroxylase EGLN2 (EGLN2) is a protein
from Homo sapiens identified by UniProt accession
Q96KS0, 407 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | Prolyl hydroxylase EGLN2 |
|---|
| UniProt accession | Q96KS0 |
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| Gene | EGLN2 |
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| Organism | Homo sapiens |
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| Length | 407 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (133)
Diseases linked to this target (Open Targets).
- hemoglobin measurement · score 0.62
- hematocrit · score 0.62
- anemia (phenotype) · score 0.58
- chronic kidney disease · score 0.56
- erythrocyte count · score 0.43
- myelodysplastic syndrome · score 0.40
- mean corpuscular hemoglobin concentration · score 0.38
- anemia · score 0.37
- red blood cell density measurement · score 0.35
- neurodegenerative disease · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96KS0-F1 | alphafold | PREDICTED | 67.80 | — |
Amino-acid sequence (407 residues)
MDSPCQPQPL SQALPQLPGS SSEPLEPEPG RARMGVESYL PCPLLPSYHC PGVPSEASAG SGTPRATATS TTASPLRDGF GGQDGGELRP LQSEGAAALV TKGCQRLAAQ GARPEAPKRK WAEDGGDAPS PSKRPWARQE NQEAEREGGM SCSCSSGSGE ASAGLMEEAL PSAPERLALD YIVPCMRYYG ICVKDSFLGA ALGGRVLAEV EALKRGGRLR DGQLVSQRAI PPRSIRGDQI AWVEGHEPGC RSIGALMAHV DAVIRHCAGR LGSYVINGRT KAMVACYPGN GLGYVRHVDN PHGDGRCITC IYYLNQNWDV KVHGGLLQIF PEGRPVVANI EPLFDRLLIF WSDRRNPHEV KPAYATRYAI TVWYFDAKER AAAKDKYQLA SGQKGVQVPV SQPPTPT
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