Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN)
Homo sapiens — UniProt Q9NWT6
Data last refreshed: (UniProt release unknown)
Key facts
Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN) is a protein from Homo sapiens identified by UniProt accession Q9NWT6, 349 residues long. MolForge cross-references it against 4 known binders and 66 disease associations.
- UniProt accession: Q9NWT6; gene symbol HIF1AN.
- Organism: Homo sapiens.
- Length: 349 amino acids.
- Top disease associations (Open Targets): mitochondrial complex I deficiency, neurodegenerative disease and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Hypoxia-inducible factor 1-alpha inhibitor |
|---|---|
| UniProt accession | Q9NWT6 |
| Gene | HIF1AN |
| Organism | Homo sapiens |
| Length | 349 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (66)
Diseases linked to this target (Open Targets).
- mitochondrial complex I deficiency · score 0.43
- neurodegenerative disease · score 0.39
- genetic disorder · score 0.17
- body mass index · score 0.15
- t-tau:beta-amyloid 1-42 ratio measurement · score 0.15
- lean body mass · score 0.12
- alkaline phosphatase measurement · score 0.11
- body height · score 0.11
- heel bone mineral density · score 0.10
- adolescent idiopathic scoliosis · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NWT6-F1 | alphafold | PREDICTED | 91.40 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NWT6.
Amino-acid sequence (349 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HIF1AN?
The strongest Open Targets associations for HIF1AN are mitochondrial complex I deficiency, neurodegenerative disease, genetic disorder, body mass index and t-tau:beta-amyloid 1-42 ratio measurement.
How long is the HIF1AN protein?
The Homo sapiens HIF1AN protein (UniProt Q9NWT6) is 349 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NWT6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NWT6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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