About Syntaxin-binding protein 3
Syntaxin-binding protein 3 (STXBP3) is a protein
from Homo sapiens identified by UniProt accession
O00186, 592 residues long.
MolForge cross-references it against 0 known binders and
79 disease associations.
Target properties
| Protein name | Syntaxin-binding protein 3 |
|---|
| UniProt accession | O00186 |
|---|
| Gene | STXBP3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 592 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (79)
Diseases linked to this target (Open Targets).
- sensorineural hearing loss · score 0.42
- breast adenocarcinoma · score 0.23
- neutrophil count · score 0.19
- ovarian carcinoma · score 0.15
- squamous cell lung carcinoma · score 0.12
- glioblastoma multiforme · score 0.11
- MODY · score 0.10
- lung adenocarcinoma · score 0.10
- head and neck squamous cell carcinoma · score 0.09
- type 2 diabetes mellitus · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00186-F1 | alphafold | PREDICTED | 89.35 | — |
Amino-acid sequence (592 residues)
MAPPVAERGL KSVVWQKIKA TVFDDCKKEG EWKIMLLDEF TTKLLASCCK MTDLLEEGIT VVENIYKNRE PVRQMKALYF ITPTSKSVDC FLHDFASKSE NKYKAAYIYF TDFCPDNLFN KIKASCSKSI RRCKEINISF IPHESQVYTL DVPDAFYYCY SPDPGNAKGK DAIMETMADQ IVTVCATLDE NPGVRYKSKP LDNASKLAQL VEKKLEDYYK IDEKSLIKGK THSQLLIIDR GFDPVSTVLH ELTFQAMAYD LLPIENDTYK YKTDGKEKEA ILEEEDDLWV RIRHRHIAVV LEEIPKLMKE ISSTKKATEG KTSLSALTQL MKKMPHFRKQ ITKQVVHLNL AEDCMNKFKL NIEKLCKTEQ DLALGTDAEG QKVKDSMRVL LPVLLNKNHD NCDKIRAILL YIFSINGTTE ENLDRLIQNV KIENESDMIR NWSYLGVPIV PQSQQGKPLR KDRSAEETFQ LSRWTPFIKD IMEDAIDNRL DSKEWPYCSQ CPAVWNGSGA VSARQKPRAN YLEDRKNGSK LIVFVIGGIT YSEVRCAYEV SQAHKSCEVI IGSTHVLTPK KLLDDIKMLN KPKDKVSLIK DE
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