About Tumor necrosis factor receptor superfamily member 10A
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is a protein
from Homo sapiens identified by UniProt accession
O00220, 468 residues long.
MolForge cross-references it against 0 known binders and
364 disease associations.
Target properties
| Protein name | Tumor necrosis factor receptor superfamily member 10A |
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| UniProt accession | O00220 |
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| Gene | TNFRSF10A |
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| Organism | Homo sapiens |
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| Length | 468 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (364)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- monocyte count · score 0.37
- age-related macular degeneration · score 0.35
- blood protein measurement · score 0.30
- central serous retinopathy · score 0.30
- head and neck squamous cell carcinoma · score 0.27
- ovarian cancer · score 0.26
- monocyte percentage of leukocytes · score 0.25
- gastric adenocarcinoma · score 0.23
- wet macular degeneration · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00220-F1 | alphafold | PREDICTED | 66.12 | — |
Amino-acid sequence (468 residues)
MAPPPARVHL GAFLAVTPNP GSAASGTEAA AATPSKVWGS SAGRIEPRGG GRGALPTSMG QHGPSARARA GRAPGPRPAR EASPRLRVHK TFKFVVVGVL LQVVPSSAAT IKLHDQSIGT QQWEHSPLGE LCPPGSHRSE HPGACNRCTE GVGYTNASNN LFACLPCTAC KSDEEERSPC TTTRNTACQC KPGTFRNDNS AEMCRKCSRG CPRGMVKVKD CTPWSDIECV HKESGNGHNI WVILVVTLVV PLLLVAVLIV CCCIGSGCGG DPKCMDRVCF WRLGLLRGPG AEDNAHNEIL SNADSLSTFV SEQQMESQEP ADLTGVTVQS PGEAQCLLGP AEAEGSQRRR LLVPANGADP TETLMLFFDK FANIVPFDSW DQLMRQLDLT KNEIDVVRAG TAGPGDALYA MLMKWVNKTG RNASIHTLLD ALERMEERHA REKIQDLLVD SGKFIYLEDG TGSAVSLE
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