About Tumor necrosis factor receptor superfamily member 11B
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is a protein
from Homo sapiens identified by UniProt accession
O00300, 401 residues long.
MolForge cross-references it against 0 known binders and
711 disease associations.
Target properties
| Protein name | Tumor necrosis factor receptor superfamily member 11B |
|---|
| UniProt accession | O00300 |
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| Gene | TNFRSF11B |
|---|
| Organism | Homo sapiens |
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| Length | 401 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (711)
Diseases linked to this target (Open Targets).
- juvenile Paget disease · score 0.70
- alkaline phosphatase measurement · score 0.46
- heel bone mineral density · score 0.43
- bone density · score 0.43
- eosinophil count · score 0.42
- bone quantitative ultrasound measurement · score 0.40
- hypothyroidism · score 0.40
- lymphocyte count · score 0.36
- hip bone mineral density · score 0.36
- Thyroid preparation use measurement · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00300-F1 | alphafold | PREDICTED | 86.48 | — |
Amino-acid sequence (401 residues)
MNNLLCCALV FLDISIKWTT QETFPPKYLH YDEETSHQLL CDKCPPGTYL KQHCTAKWKT VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT HNRVCECKEG RYLEIEFCLK HRSCPPGFGV VQAGTPERNT VCKRCPDGFF SNETSSKAPC RKHTNCSVFG LLLTQKGNAT HDNICSGNSE STQKCGIDVT LCEEAFFRFA VPTKFTPNWL SVLVDNLPGT KVNAESVERI KRQHSSQEQT FQLLKLWKHQ NKDQDIVKKI IQDIDLCENS VQRHIGHANL TFEQLRSLME SLPGKKVGAE DIEKTIKACK PSDQILKLLS LWRIKNGDQD TLKGLMHALK HSKTYHFPKT VTQSLKKTIR FLHSFTMYKL YQKLFLEMIG NQVQSVKISC L
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