Synaptotagmin-5 (SYT5)

About Synaptotagmin-5

Synaptotagmin-5 (SYT5) is a protein from Homo sapiens identified by UniProt accession O00445, 386 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	Synaptotagmin-5
UniProt accession	O00445
Gene	SYT5
Organism	Homo sapiens
Length	386 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

monocyte count · score 0.29
platelet component distribution width · score 0.25
Drugs used in diabetes use measurement · score 0.24
platelet count · score 0.20
mean reticulocyte volume · score 0.18
platelet crit · score 0.18
mean corpuscular hemoglobin concentration · score 0.10
mean corpuscular volume · score 0.08
reticulocyte measurement · score 0.08
reticulocyte count · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00445-F1	alphafold	PREDICTED	83.90	—

Amino-acid sequence (386 residues)

MFPEPPTPGP PSPDTPPDSS RISHGPVPPW ALATIVLVSG LLIFSCCFCL YRKSCRRRTG KKSQAQAQVH LQEVKGLGQS YIDKVQPEVE ELEPAPSGPG QQVADKHELG RLQYSLDYDF QSGQLLVGIL QAMGLAALDL GGSSDPYVRV YLLPDKRRRY ETKVHRQTLN PHFGETFAFK VPYVELGGRV LVMAVYDFDR FSRNDAIGEV RVPMSSVDLG RPVQAWRELQ AAPREEQEKL GDICFSLRYV PTAGKLTVIV LEAKNLKKMD VGGLSDPYVK VHLLQGGKKV RKKKTTIKKN TLNPYYNEAF SFEVPCDQVQ KVQVELTVLD YDKLGKNEAI GRVAVGAAAG GAGLRHWADM LANPRRPIAQ WHSLRPPDRV RLLPAP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards