Leukocyte-specific transcript 1 protein (LST1)

About Leukocyte-specific transcript 1 protein

Leukocyte-specific transcript 1 protein (LST1) is a protein from Homo sapiens identified by UniProt accession O00453, 97 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	Leukocyte-specific transcript 1 protein
UniProt accession	O00453
Gene	LST1
Organism	Homo sapiens
Length	97 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

bone measurement · score 0.35
bone density · score 0.29
bone mineral content measurement · score 0.26
cognitive function measurement · score 0.22
systemic lupus erythematosus · score 0.19
inflammatory bowel disease · score 0.13
mathematical ability · score 0.05
blood protein measurement · score 0.05
MHC class I polypeptide-related sequence B measurement · score 0.04
FEV/FVC ratio · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00453-F1	alphafold	PREDICTED	70.42	—

Amino-acid sequence (97 residues)

MLSRNDDICI YGGLGLGGLL LLAVVLLSAC LCWLHRRVKR LERSWAQGSS EQELHYASLQ RLPVPSSEGP DLRGRDKRGT KEDPRADYAC IAENKPT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards