Importin subunit alpha-4 (KPNA3)

About Importin subunit alpha-4

Importin subunit alpha-4 (KPNA3) is a protein from Homo sapiens identified by UniProt accession O00505, 521 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.

Target properties

Protein name	Importin subunit alpha-4
UniProt accession	O00505
Gene	KPNA3
Organism	Homo sapiens
Length	521 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (65)

Diseases linked to this target (Open Targets).

influenza · score 0.46
Autosomal dominant spastic paraplegia type 37 · score 0.37
autosomal dominant pure spastic paraplegia · score 0.37
reticulocyte count · score 0.37
FEV/FVC ratio · score 0.35
reticulocyte measurement · score 0.27
Alzheimer disease · score 0.24
Parkinson disease · score 0.24
neurodegenerative disease · score 0.24
lysosomal storage disease · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00505-F1	alphafold	PREDICTED	86.49	—

Amino-acid sequence (521 residues)

MAENPSLENH RIKSFKNKGR DVETMRRHRN EVTVELRKNK RDEHLLKKRN VPQEESLEDS DVDADFKAQN VTLEAILQNA TSDNPVVQLS AVQAARKLLS SDRNPPIDDL IKSGILPILV KCLERDDNPS LQFEAAWALT NIASGTSAQT QAVVQSNAVP LFLRLLRSPH QNVCEQAVWA LGNIIGDGPQ CRDYVISLGV VKPLLSFISP SIPITFLRNV TWVIVNLCRN KDPPPPMETV QEILPALCVL IYHTDINILV DTVWALSYLT DGGNEQIQMV IDSGVVPFLV PLLSHQEVKV QTAALRAVGN IVTGTDEQTQ VVLNCDVLSH FPNLLSHPKE KINKEAVWFL SNITAGNQQQ VQAVIDAGLI PMIIHQLAKG DFGTQKEAAW AISNLTISGR KDQVEYLVQQ NVIPPFCNLL SVKDSQVVQV VLDGLKNILI MAGDEASTIA EIIEECGGLE KIEVLQQHEN EDIYKLAFEI IDQYFSGDDI DEDPCLIPEA TQGGTYNFDP TANLQTKEFN F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards