Serine/threonine-protein kinase 25 (STK25)

About Serine/threonine-protein kinase 25

Serine/threonine-protein kinase 25 (STK25) is a protein from Homo sapiens identified by UniProt accession O00506, 426 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.

Target properties

Protein name	Serine/threonine-protein kinase 25
UniProt accession	O00506
Gene	STK25
Organism	Homo sapiens
Length	426 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (8)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (95)

Diseases linked to this target (Open Targets).

Parkinson disease · score 0.27
Alzheimer disease · score 0.27
neurodegenerative disease · score 0.27
lysosomal storage disease · score 0.27
multiple sclerosis · score 0.27
Thyroid preparation use measurement · score 0.24
pulse pressure measurement · score 0.21
thyroid disease · score 0.17
basophil percentage of leukocytes · score 0.15
Anilide use measurement · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00506-F1	alphafold	PREDICTED	79.71	—

Amino-acid sequence (426 residues)

MAHLRGFANQ HSRVDPEELF TKLDRIGKGS FGEVYKGIDN HTKEVVAIKI IDLEEAEDEI EDIQQEITVL SQCDSPYITR YFGSYLKSTK LWIIMEYLGG GSALDLLKPG PLEETYIATI LREILKGLDY LHSERKIHRD IKAANVLLSE QGDVKLADFG VAGQLTDTQI KRNTFVGTPF WMAPEVIKQS AYDFKADIWS LGITAIELAK GEPPNSDLHP MRVLFLIPKN SPPTLEGQHS KPFKEFVEAC LNKDPRFRPT AKELLKHKFI TRYTKKTSFL TELIDRYKRW KSEGHGEESS SEDSDIDGEA EDGEQGPIWT FPPTIRPSPH SKLHKGTALH SSQKPAEPVK RQPRSQCLST LVRPVFGELK EKHKQSGGSV GALEELENAF SLAEESCPGI SDKLMVHLVE RVQRFSHNRN HLTSTR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards