Pyridoxal kinase (PDXK)

About Pyridoxal kinase

Pyridoxal kinase (PDXK) is a protein from Homo sapiens identified by UniProt accession O00764, 312 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.

Target properties

Protein name	Pyridoxal kinase
UniProt accession	O00764
Gene	PDXK
Organism	Homo sapiens
Length	312 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (104)

Diseases linked to this target (Open Targets).

hereditary motor and sensory neuropathy type 6 · score 0.51
neurodegenerative disease · score 0.43
neuroinflammatory disorder · score 0.37
cystatin B measurement · score 0.16
metabolite measurement · score 0.12
drug use measurement · score 0.10
hepatocellular carcinoma · score 0.08
systolic blood pressure · score 0.07
diastolic blood pressure · score 0.07
Miyoshi myopathy · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00764-F1	alphafold	PREDICTED	95.83	—

Amino-acid sequence (312 residues)

MEEECRVLSI QSHVIRGYVG NRAATFPLQV LGFEIDAVNS VQFSNHTGYA HWKGQVLNSD ELQELYEGLR LNNMNKYDYV LTGYTRDKSF LAMVVDIVQE LKQQNPRLVY VCDPVLGDKW DGEGSMYVPE DLLPVYKEKV VPLADIITPN QFEAELLSGR KIHSQEEALR VMDMLHSMGP DTVVITSSDL PSPQGSNYLI VLGSQRRRNP AGSVVMERIR MDIRKVDAVF VGTGDLFAAM LLAWTHKHPN NLKVACEKTV STLHHVLQRT IQCAKAQAGE GVRPSPMQLE LRMVQSKRDI EDPEIVVQAT VL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards