Dexrabeprazole

ALIMENTARY TRACT AND METABOLISM

Key facts

Dexrabeprazole is a drug catalogued in DrugCentral. DrugCentral lists 24 molecular targets, including RET, FLT1 and FLT4. Recorded indications include Duodenal ulcer disease, Duodenal Ulcer due to H. Pylori, Erosive esophagitis and Gastric Hypersecretory Conditions.

• Molecular targets: RET, FLT1, FLT4 and DDR1 (24 listed in DrugCentral).
• Indications: Duodenal ulcer disease, Duodenal Ulcer due to H. Pylori, Erosive esophagitis, Gastric Hypersecretory Conditions and Gastric ulcer and others.
• ATC code: A02BC07 (Proton pump inhibitors).
• Molecular formula: C18H21N3O3S; molecular weight 359.44 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (11)

• Duodenal ulcer disease
• Duodenal Ulcer due to H. Pylori
• Erosive esophagitis
• Gastric Hypersecretory Conditions
• Gastric ulcer
• Gastroesophageal reflux disease
• Maintenance of Healing Erosive Esophagitis
• Pathological Gastric Hypersecretory Condition
• Peptic reflux disease
• Peptic ulcer
• Zollinger-Ellison syndrome

Off-label uses (1)

• Upper gastrointestinal hemorrhage

Contraindications (10)

• Acute nephropathy
• Atrophic gastritis
• Chronic heart failure
• Disease of liver
• Edema
• Fracture of bone
• Hepatic failure
• Hypomagnesemia
• Oliguria
• Osteoporosis

Mechanism & targets

Molecular targets (24)

Target	Gene	Action	Activity
Proto-oncogene tyrosine-protein kinase receptor Ret	RET	unknown	Kd 8.30
Vascular endothelial growth factor receptor 1	FLT1	unknown	IC50 8.15
Vascular endothelial growth factor receptor 3	FLT4	unknown	IC50 8.00
Epithelial discoidin domain-containing receptor 1	DDR1	unknown	Kd 7.85
Fibroblast growth factor receptor 1	FGFR1	unknown	IC50 7.76
Vascular endothelial growth factor receptor 2	KDR	unknown	IC50 7.60
Fibroblast growth factor receptor 2	FGFR2	unknown	IC50 7.08
Discoidin domain-containing receptor 2	DDR2	unknown	Kd 7.03
Receptor-interacting serine/threonine-protein kinase 2	RIPK2	unknown	Kd 6.70
Fibroblast growth factor receptor 3	FGFR3	unknown	IC50 6.62
Platelet-derived growth factor receptor beta	PDGFRB	unknown	Kd 6.56
D(3) dopamine receptor	DRD3	unknown	Ki 6.10
Alpha-2B adrenergic receptor	ADRA2B	unknown	Ki 6.10
Adenosine receptor A3	ADORA3	unknown	Ki 5.74
Tyrosine-protein kinase Lyn	LYN	unknown	Kd 5.56
Sterile alpha and TIR motif-containing protein 1	SARM1	unknown	IC50 5.50
Cytosolic endo-beta-N-acetylglucosaminidase	ENGASE	unknown	IC50 5.35
Fatty acid synthase	FASN	unknown	Ki 5.23
ATP-binding cassette sub-family G member 2	ABCG2	unknown	IC50 5.07
Insulin-degrading enzyme	IDE	unknown	IC50 4.96

ATC classification

ATC code	Therapeutic hierarchy
A02BC07	ALIMENTARY TRACT AND METABOLISM › DRUGS FOR ACID RELATED DISORDERS › DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) › Proton pump inhibitors

Chemical structure

• Molecular formula: C₁₈H₂₁N₃O₃S
• Molecular weight: 359.44 g/mol
• CAS number: 177795-60-7
• InChIKey: YREYEVIYCVEVJK-RUZDIDTESA-N
• PubChem CID: 9906855

COCCCOC1=CC=NC(C[S@@](=O)C2=NC3=C(N2)C=CC=C3)=C1C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Dexrabeprazole used for?

DrugCentral lists the following indications for Dexrabeprazole: Duodenal ulcer disease, Duodenal Ulcer due to H. Pylori, Erosive esophagitis, Gastric Hypersecretory Conditions, Gastric ulcer, Gastroesophageal reflux disease, Maintenance of Healing Erosive Esophagitis and Pathological Gastric Hypersecretory Condition and others.

How does Dexrabeprazole work?

Its molecular targets in DrugCentral include RET, FLT1, FLT4 and DDR1.

What is the chemical formula of Dexrabeprazole?

Dexrabeprazole has the molecular formula C18H21N3O3S and a molecular weight of 359.44 g/mol.

Sources

• DrugCentral drug card 4867 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200930 — compound record and bioactivity
• PubChem CID 9906855 — chemical identifiers
• DrugBank DB13762 — drug record
• FDA UNII 65JK8810RM — substance identity
• UniProt P07949 (RET) — target protein
• UniProt P17948 (FLT1) — target protein
• UniProt P35916 (FLT4) — target protein
• UniProt Q08345 (DDR1) — target protein
• UniProt P11362 (FGFR1) — target protein
• UniProt P35968 (KDR) — target protein

How this page is built: methodology · editorial policy & corrections.