Cytosolic endo-beta-N-acetylglucosaminidase (ENGASE)
Homo sapiens — UniProt Q8NFI3
Data last refreshed: (UniProt release unknown)
Key facts
Cytosolic endo-beta-N-acetylglucosaminidase (ENGASE) is a protein from Homo sapiens identified by UniProt accession Q8NFI3, 743 residues long. MolForge cross-references it against 5 known binders and 28 disease associations.
- UniProt accession: Q8NFI3; gene symbol ENGASE.
- Organism: Homo sapiens.
- Length: 743 amino acids.
- Top disease associations (Open Targets): FEV/FVC ratio, response to angiotensin-converting enzyme inhibitor and endophthalmitis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytosolic endo-beta-N-acetylglucosaminidase |
|---|---|
| UniProt accession | Q8NFI3 |
| Gene | ENGASE |
| Organism | Homo sapiens |
| Length | 743 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.37
- response to angiotensin-converting enzyme inhibitor · score 0.10
- endophthalmitis · score 0.09
- 3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.06
- 3-hydroxypropylmercapturic acid measurement · score 0.06
- Orofacial cleft · score 0.06
- metastasis measurement · score 0.04
- disease progression measurement · score 0.04
- pancreatic adenocarcinoma · score 0.04
- body mass index · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NFI3-F1 | alphafold | PREDICTED | 85.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NFI3.
Amino-acid sequence (743 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ENGASE?
The strongest Open Targets associations for ENGASE are FEV/FVC ratio, response to angiotensin-converting enzyme inhibitor, endophthalmitis, 3-hydroxy-1-methylpropylmercapturic acid measurement and 3-hydroxypropylmercapturic acid measurement.
How long is the ENGASE protein?
The Homo sapiens ENGASE protein (UniProt Q8NFI3) is 743 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NFI3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NFI3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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