About Receptor-interacting serine/threonine-protein kinase 2
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) is a protein
from Homo sapiens identified by UniProt accession
O43353, 540 residues long.
MolForge cross-references it against 0 known binders and
247 disease associations.
Target properties
| Protein name | Receptor-interacting serine/threonine-protein kinase 2 |
|---|
| UniProt accession | O43353 |
|---|
| Gene | RIPK2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 540 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (247)
Diseases linked to this target (Open Targets).
- leprosy · score 0.43
- neurodegenerative disease · score 0.34
- protein measurement · score 0.33
- Crohn's disease · score 0.30
- ulcer disease · score 0.28
- Oral ulcer · score 0.28
- ulcerative colitis · score 0.27
- sclerosing cholangitis · score 0.27
- psoriasis · score 0.27
- ankylosing spondylitis · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43353-F1 | alphafold | PREDICTED | 76.03 | — |
Amino-acid sequence (540 residues)
MNGEAICSAL PTIPYHKLAD LRYLSRGASG TVSSARHADW RVQVAVKHLH IHTPLLDSER KDVLREAEIL HKARFSYILP ILGICNEPEF LGIVTEYMPN GSLNELLHRK TEYPDVAWPL RFRILHEIAL GVNYLHNMTP PLLHHDLKTQ NILLDNEFHV KIADFGLSKW RMMSLSQSRS SKSAPEGGTI IYMPPENYEP GQKSRASIKH DIYSYAVITW EVLSRKQPFE DVTNPLQIMY SVSQGHRPVI NEESLPYDIP HRARMISLIE SGWAQNPDER PSFLKCLIEL EPVLRTFEEI TFLEAVIQLK KTKLQSVSSA IHLCDKKKME LSLNIPVNHG PQEESCGSSQ LHENSGSPET SRSLPAPQDN DFLSRKAQDC YFMKLHHCPG NHSWDSTISG SQRAAFCDHK TTPCSSAIIN PLSTAGNSER LQPGIAQQWI QSKREDIVNQ MTEACLNQSL DALLSRDLIM KEDYELVSTK PTRTSKVRQL LDTTDIQGEE FAKVIVQKLK DNKQMGLQPY PEILVVSRSP SLNLLQNKSM
Explore Receptor-interacting serine/threonine-protein kinase 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets