Icotinib

ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

Key facts

Icotinib is a drug catalogued in DrugCentral. DrugCentral lists 9 molecular targets, including EGFR, STK10 and CARS. Recorded indications include Non-small cell lung cancer.

• Molecular targets: EGFR, STK10, CARS and GAK (9 listed in DrugCentral).
• Indications: Non-small cell lung cancer.
• ATC code: L01EB08 (Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors).
• Molecular formula: C22H21N3O4; molecular weight 391.43 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Non-small cell lung cancer

Mechanism & targets

Molecular targets (9)

Target	Gene	Action	Activity
Epidermal growth factor receptor	EGFR	inhibitor	IC50 8.70
Serine/threonine-protein kinase 10	STK10	unknown	Kd 6.64
Cysteine--tRNA ligase, cytoplasmic	CARS	unknown	Kd 6.19
Cyclin-G-associated kinase	GAK	unknown	Kd 6.14
STE20-like serine/threonine-protein kinase	SLK	unknown	Kd 5.98
Receptor-interacting serine/threonine-protein kinase 2	RIPK2	unknown	Kd 5.58
Mitotic checkpoint serine/threonine-protein kinase BUB1	BUB1	unknown	Kd 5.54
Mitogen-activated protein kinase kinase kinase 1	MAP3K1	unknown	Kd 5.38
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	PIP4K2C	unknown	Kd 5.33

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	China Food and Drug Administration (CFDA)	—	Zhejiang Beta Pharma Inc.

ATC classification

ATC code	Therapeutic hierarchy
L01EB08	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › ANTINEOPLASTIC AGENTS › PROTEIN KINASE INHIBITORS › Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Icotinib is on its molecule page.

• Molecular formula: C₂₂H₂₁N₃O₄
• Molecular weight: 391.43 g/mol
• CAS number: —
• InChIKey: QQLKULDARVNMAL-UHFFFAOYSA-N
• PubChem CID: 22024915

C#CC1=CC=CC(NC2=NC=NC3=C2C=C2OCCOCCOCCOC2=C3)=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Icotinib used for?

DrugCentral lists the following indications for Icotinib: Non-small cell lung cancer.

How does Icotinib work?

Its molecular targets in DrugCentral include EGFR (inhibitor), STK10, CARS and GAK.

What is the chemical formula of Icotinib?

Icotinib has the molecular formula C22H21N3O4 and a molecular weight of 391.43 g/mol.

Sources

• DrugCentral drug card 5209 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2087361 — compound record and bioactivity
• PubChem CID 22024915 — chemical identifiers
• DrugBank DB11737 — drug record
• FDA UNII 9G6U5L461Q — substance identity
• UniProt P00533 (EGFR) — target protein
• UniProt O94804 (STK10) — target protein
• UniProt P49589 (CARS) — target protein
• UniProt O14976 (GAK) — target protein
• UniProt Q9H2G2 (SLK) — target protein
• UniProt O43353 (RIPK2) — target protein

How this page is built: methodology · editorial policy & corrections.