Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C)
Homo sapiens — UniProt Q8TBX8
Data last refreshed: (UniProt release unknown)
Key facts
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C) is a protein from Homo sapiens identified by UniProt accession Q8TBX8, 421 residues long. MolForge cross-references it against 11 known binders and 187 disease associations.
- UniProt accession: Q8TBX8; gene symbol PIP4K2C.
- Organism: Homo sapiens.
- Length: 421 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neuroinflammatory disorder and pancreatic adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma |
|---|---|
| UniProt accession | Q8TBX8 |
| Gene | PIP4K2C |
| Organism | Homo sapiens |
| Length | 421 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (187)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- neuroinflammatory disorder · score 0.35
- pancreatic adenocarcinoma · score 0.29
- glioblastoma multiforme · score 0.29
- breast adenocarcinoma · score 0.29
- low grade glioma · score 0.29
- thyroid gland adenocarcinoma · score 0.29
- lung adenocarcinoma · score 0.26
- head and neck squamous cell carcinoma · score 0.26
- squamous cell lung carcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TBX8-F1 | alphafold | PREDICTED | 80.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TBX8.
Amino-acid sequence (421 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIP4K2C?
The strongest Open Targets associations for PIP4K2C are neurodegenerative disease, neuroinflammatory disorder, pancreatic adenocarcinoma, glioblastoma multiforme and breast adenocarcinoma.
How long is the PIP4K2C protein?
The Homo sapiens PIP4K2C protein (UniProt Q8TBX8) is 421 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TBX8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TBX8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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