STE20-like serine/threonine-protein kinase (SLK)
Homo sapiens — UniProt Q9H2G2
Data last refreshed: (UniProt release unknown)
Key facts
STE20-like serine/threonine-protein kinase (SLK) is a protein from Homo sapiens identified by UniProt accession Q9H2G2, 1235 residues long. MolForge cross-references it against 24 known binders and 67 disease associations.
- UniProt accession: Q9H2G2; gene symbol SLK.
- Organism: Homo sapiens.
- Length: 1235 amino acids.
- Target class: Kinase.
- Top disease associations (Open Targets): neurodegenerative disease, red blood cell density measurement and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | STE20-like serine/threonine-protein kinase |
|---|---|
| UniProt accession | Q9H2G2 |
| Gene | SLK |
| Organism | Homo sapiens |
| Length | 1235 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Kinase (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (67)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- red blood cell density measurement · score 0.36
- mean corpuscular volume · score 0.31
- diastolic blood pressure · score 0.30
- mean corpuscular hemoglobin · score 0.28
- erythrocyte count · score 0.27
- platelet count · score 0.27
- mean corpuscular hemoglobin concentration · score 0.26
- uterine fibroid · score 0.25
- mean arterial pressure · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2G2-F1 | alphafold | PREDICTED | 64.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2G2.
Amino-acid sequence (1235 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLK?
The strongest Open Targets associations for SLK are neurodegenerative disease, red blood cell density measurement, mean corpuscular volume, diastolic blood pressure and mean corpuscular hemoglobin.
How long is the SLK protein?
The Homo sapiens SLK protein (UniProt Q9H2G2) is 1235 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2G2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2G2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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