About Tyrosine-protein kinase Lyn
Tyrosine-protein kinase Lyn (LYN) is a protein
from Homo sapiens identified by UniProt accession
P07948, 512 residues long.
MolForge cross-references it against 0 known binders and
848 disease associations.
Target properties
| Protein name | Tyrosine-protein kinase Lyn |
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| UniProt accession | P07948 |
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| Gene | LYN |
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| Organism | Homo sapiens |
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| Length | 512 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (848)
Diseases linked to this target (Open Targets).
- autoinflammatory disease, systemic, with vasculitis · score 0.61
- chronic myelogenous leukemia · score 0.61
- cancer · score 0.58
- acute lymphoblastic leukemia · score 0.56
- neurodegenerative disease · score 0.53
- neoplasm · score 0.49
- mean platelet volume · score 0.47
- cutaneous Leishmaniasis · score 0.46
- multiple myeloma · score 0.46
- lymphoid leukemia · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07948-F1 | alphafold | PREDICTED | 83.15 | — |
Amino-acid sequence (512 residues)
MGCIKSKGKD SLSDDGVDLK TQPVRNTERT IYVRDPTSNK QQRPVPESQL LPGQRFQTKD PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLLTKKE GFIPSNYVAK LNTLETEEWF FKDITRKDAE RQLLAPGNSA GAFLIRESET LKGSFSLSVR DFDPVHGDVI KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQADGLCR RLEKACISPK PQKPWDKDAW EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRVENCPD ELYDIMKMCW KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP
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