About Fibroblast growth factor receptor 3
Fibroblast growth factor receptor 3 (FGFR3) is a protein
from Homo sapiens identified by UniProt accession
P22607, 806 residues long.
MolForge cross-references it against 0 known binders and
1,837 disease associations.
Target properties
| Protein name | Fibroblast growth factor receptor 3 |
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| UniProt accession | P22607 |
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| Gene | FGFR3 |
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| Organism | Homo sapiens |
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| Length | 806 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1837)
Diseases linked to this target (Open Targets).
- thanatophoric dysplasia type 1 · score 0.84
- Achondroplasia · score 0.83
- Muenke syndrome · score 0.82
- Severe achondroplasia - developmental delay - acanthosis nigricans · score 0.81
- thanatophoric dysplasia type 2 · score 0.81
- hypochondroplasia · score 0.81
- Crouzon syndrome - acanthosis nigricans · score 0.79
- Camptodactyly - tall stature - scoliosis - hearing loss · score 0.77
- urinary bladder cancer · score 0.76
- camptodactyly-tall stature-scoliosis-hearing loss syndrome · score 0.76
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22607-F1 | alphafold | PREDICTED | 74.21 | — |
Amino-acid sequence (806 residues)
MGAPACALAL CVAVAIVAGA SSESLGTEQR VVGRAAEVPG PEPGQQEQLV FGSGDAVELS CPPPGGGPMG PTVWVKDGTG LVPSERVLVG PQRLQVLNAS HEDSGAYSCR QRLTQRVLCH FSVRVTDAPS SGDDEDGEDE AEDTGVDTGA PYWTRPERMD KKLLAVPAAN TVRFRCPAAG NPTPSISWLK NGREFRGEHR IGGIKLRHQQ WSLVMESVVP SDRGNYTCVV ENKFGSIRQT YTLDVLERSP HRPILQAGLP ANQTAVLGSD VEFHCKVYSD AQPHIQWLKH VEVNGSKVGP DGTPYVTVLK TAGANTTDKE LEVLSLHNVT FEDAGEYTCL AGNSIGFSHH SAWLVVLPAE EELVEADEAG SVYAGILSYG VGFFLFILVV AAVTLCRLRS PPKKGLGSPT VHKISRFPLK RQVSLESNAS MSSNTPLVRI ARLSSGEGPT LANVSELELP ADPKWELSRA RLTLGKPLGE GCFGQVVMAE AIGIDKDRAA KPVTVAVKML KDDATDKDLS DLVSEMEMMK MIGKHKNIIN LLGACTQGGP LYVLVEYAAK GNLREFLRAR RPPGLDYSFD TCKPPEEQLT FKDLVSCAYQ VARGMEYLAS QKCIHRDLAA RNVLVTEDNV MKIADFGLAR DVHNLDYYKK TTNGRLPVKW MAPEALFDRV YTHQSDVWSF GVLLWEIFTL GGSPYPGIPV EELFKLLKEG HRMDKPANCT HDLYMIMREC WHAAPSQRPT FKQLVEDLDR VLTVTSTDEY LDLSAPFEQY SPGGQDTPSS SSSGDDSVFA HDLLPPAPPS SGGSRT
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