About Immunoglobulin superfamily containing leucine-rich repeat protein
Immunoglobulin superfamily containing leucine-rich repeat protein (ISLR) is a protein
from Homo sapiens identified by UniProt accession
O14498, 428 residues long.
MolForge cross-references it against 0 known binders and
112 disease associations.
Target properties
| Protein name | Immunoglobulin superfamily containing leucine-rich repeat protein |
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| UniProt accession | O14498 |
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| Gene | ISLR |
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| Organism | Homo sapiens |
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| Length | 428 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (112)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- breast adenocarcinoma · score 0.25
- optic disc size measurement · score 0.24
- cups of coffee per day measurement · score 0.13
- blood protein measurement · score 0.12
- glomerular filtration rate · score 0.11
- neoplasm · score 0.09
- non-small cell lung carcinoma · score 0.09
- urate measurement · score 0.08
- Testicular regression syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14498-F1 | alphafold | PREDICTED | 80.46 | — |
Amino-acid sequence (428 residues)
MQELHLLWWA LLLGLAQACP EPCDCGEKYG FQIADCAYRD LESVPPGFPA NVTTLSLSAN RLPGLPEGAF REVPLLQSLW LAHNEIRTVA AGALASLSHL KSLDLSHNLI SDFAWSDLHN LSALQLLKMD SNELTFIPRD AFRSLRALRS LQLNHNRLHT LAEGTFTPLT ALSHLQINEN PFDCTCGIVW LKTWALTTAV SIPEQDNIAC TSPHVLKGTP LSRLPPLPCS APSVQLSYQP SQDGAELRPG FVLALHCDVD GQPAPQLHWH IQIPSGIVEI TSPNVGTDGR ALPGTPVASS QPRFQAFANG SLLIPDFGKL EEGTYSCLAT NELGSAESSV DVALATPGEG GEDTLGRRFH GKAVEGKGCY TVDNEVQPSG PEDNVVIIYL SRAGNPEAAV AEGVPGQLPP GLLLLGQSLL LFFFLTSF
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