About Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3) is a protein
from Homo sapiens identified by UniProt accession
O14638, 875 residues long.
MolForge cross-references it against 0 known binders and
252 disease associations.
Target properties
| Protein name | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 |
|---|
| UniProt accession | O14638 |
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| Gene | ENPP3 |
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| Organism | Homo sapiens |
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| Length | 875 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (252)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.39
- vitamin D measurement · score 0.38
- blood phosphate measurement · score 0.37
- type 2 diabetes mellitus · score 0.34
- cortical surface area measurement · score 0.33
- body mass index · score 0.28
- testosterone measurement · score 0.21
- serum metabolite measurement · score 0.21
- glomerular filtration rate · score 0.20
- creatinine measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14638-F1 | alphafold | PREDICTED | 95.33 | — |
Amino-acid sequence (875 residues)
MESTLTLATE QPVKKNTLKK YKIACIVLLA LLVIMSLGLG LGLGLRKLEK QGSCRKKCFD ASFRGLENCR CDVACKDRGD CCWDFEDTCV ESTRIWMCNK FRCGETRLEA SLCSCSDDCL QRKDCCADYK SVCQGETSWL EENCDTAQQS QCPEGFDLPP VILFSMDGFR AEYLYTWDTL MPNINKLKTC GIHSKYMRAM YPTKTFPNHY TIVTGLYPES HGIIDNNMYD VNLNKNFSLS SKEQNNPAWW HGQPMWLTAM YQGLKAATYF WPGSEVAING SFPSIYMPYN GSVPFEERIS TLLKWLDLPK AERPRFYTMY FEEPDSSGHA GGPVSARVIK ALQVVDHAFG MLMEGLKQRN LHNCVNIILL ADHGMDQTYC NKMEYMTDYF PRINFFYMYE GPAPRIRAHN IPHDFFSFNS EEIVRNLSCR KPDQHFKPYL TPDLPKRLHY AKNVRIDKVH LFVDQQWLAV RSKSNTNCGG GNHGYNNEFR SMEAIFLAHG PSFKEKTEVE PFENIEVYNL MCDLLRIQPA PNNGTHGSLN HLLKVPFYEP SHAEEVSKFS VCGFANPLPT ESLDCFCPHL QNSTQLEQVN QMLNLTQEEI TATVKVNLPF GRPRVLQKNV DHCLLYHREY VSGFGKAMRM PMWSSYTVPQ LGDTSPLPPT VPDCLRADVR VPPSESQKCS FYLADKNITH GFLYPPASNR TSDSQYDALI TSNLVPMYEE FRKMWDYFHS VLLIKHATER NGVNVVSGPI FDYNYDGHFD APDEITKHLA NTDVPIPTHY FVVLTSCKNK SHTPENCPGW LDVLPFIIPH RPTNVESCPE GKPEALWVEE RFTAHIARVR DVELLTGLDF YQDKVQPVSE ILQLKTYLPT FETTI
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