About Torsin-1A
Torsin-1A (TOR1A) is a protein
from Homo sapiens identified by UniProt accession
O14656, 332 residues long.
MolForge cross-references it against 0 known binders and
447 disease associations.
Target properties
| Protein name | Torsin-1A |
|---|
| UniProt accession | O14656 |
|---|
| Gene | TOR1A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 332 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (447)
Diseases linked to this target (Open Targets).
- early-onset generalized limb-onset dystonia · score 0.78
- arthrogryposis multiplex congenita 5 · score 0.76
- dystonic disorder · score 0.64
- Rapid-onset dystonia-parkinsonism · score 0.55
- Dystonia · score 0.48
- genetic disorder · score 0.45
- neutrophil count · score 0.27
- C-reactive protein measurement · score 0.24
- lung adenocarcinoma · score 0.18
- prostate carcinoma · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14656-F1 | alphafold | PREDICTED | 85.38 | — |
Amino-acid sequence (332 residues)
MKLGRAVLGL LLLAPSVVQA VEPISLGLAL AGVLTGYIYP RLYCLFAECC GQKRSLSREA LQKDLDDNLF GQHLAKKIIL NAVFGFINNP KPKKPLTLSL HGWTGTGKNF VSKIIAENIY EGGLNSDYVH LFVATLHFPH ASNITLYKDQ LQLWIRGNVS ACARSIFIFD EMDKMHAGLI DAIKPFLDYY DLVDGVSYQK AMFIFLSNAG AERITDVALD FWRSGKQRED IKLKDIEHAL SVSVFNNKNS GFWHSSLIDR NLIDYFVPFL PLEYKHLKMC IRVEMQSRGY EIDEDIVSRV AEEMTFFPKE ERVFSDKGCK TVFTKLDYYY DD
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