Torsin-1B (TOR1B)

About Torsin-1B

Torsin-1B (TOR1B) is a protein from Homo sapiens identified by UniProt accession O14657, 336 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	Torsin-1B
UniProt accession	O14657
Gene	TOR1B
Organism	Homo sapiens
Length	336 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

serum alanine aminotransferase measurement · score 0.30
aspartate aminotransferase measurement · score 0.21
liver fat measurement · score 0.21
prostate carcinoma · score 0.11
breast cancer · score 0.07
hip bone mineral density · score 0.06
hip bone size · score 0.06
amyloidosis · score 0.05
eosinophil peroxidase deficiency · score 0.05
neutropenia, severe congenital, 2, autosomal dominant · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14657-F1	alphafold	PREDICTED	85.12	—

Amino-acid sequence (336 residues)

MLRAGWLRGA AALALLLAAR VVAAFEPITV GLAIGAASAI TGYLSYNDIY CRFAECCREE RPLNASALKL DLEEKLFGQH LATEVIFKAL TGFRNNKNPK KPLTLSLHGW AGTGKNFVSQ IVAENLHPKG LKSNFVHLFV STLHFPHEQK IKLYQDQLQK WIRGNVSACA NSVFIFDEMD KLHPGIIDAI KPFLDYYEQV DGVSYRKAIF IFLSNAGGDL ITKTALDFWR AGRKREDIQL KDLEPVLSVG VFNNKHSGLW HSGLIDKNLI DYFIPFLPLE YRHVKMCVRA EMRARGSAID EDIVTRVAEE MTFFPRDEKI YSDKGCKTVQ SRLDFH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards