Syntaxin-16 (STX16)

About Syntaxin-16

Syntaxin-16 (STX16) is a protein from Homo sapiens identified by UniProt accession O14662, 325 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Syntaxin-16
UniProt accession	O14662
Gene	STX16
Organism	Homo sapiens
Length	325 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

pseudohypoparathyroidism type 1B · score 0.62
hemoglobin measurement · score 0.20
genetic disorder · score 0.19
hematocrit · score 0.18
autosomal dominant pseudohypoaldosteronism type 1 · score 0.17
mean corpuscular hemoglobin concentration · score 0.13
bowel opening frequency · score 0.12
visual perception measurement · score 0.09
birth weight · score 0.06
platelet component distribution width · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14662-F1	alphafold	PREDICTED	76.46	—

Amino-acid sequence (325 residues)

MATRRLTDAF LLLRNNSIQN RQLLAEQVSS HITSSPLHSR SIAAELDELA DDRMALVSGI SLDPEAAIGV TKRPPPKWVD GVDEIQYDVG RIKQKMKELA SLHDKHLNRP TLDDSSEEEH AIEITTQEIT QLFHRCQRAV QALPSRARAC SEQEGRLLGN VVASLAQALQ ELSTSFRHAQ SGYLKRMKNR EERSQHFFDT SVPLMDDGDD NTLYHRGFTE DQLVLVEQNT LMVEEREREI RQIVQSISDL NEIFRDLGAM IVEQGTVLDR IDYNVEQSCI KTEDGLKQLH KAEQYQKKNR KMLVILILFV IIIVLIVVLV GVKSR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards