About Lysosomal cobalamin transporter ABCD4
Lysosomal cobalamin transporter ABCD4 (ABCD4) is a protein
from Homo sapiens identified by UniProt accession
O14678, 606 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Lysosomal cobalamin transporter ABCD4 |
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| UniProt accession | O14678 |
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| Gene | ABCD4 |
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| Organism | Homo sapiens |
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| Length | 606 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (39)
Diseases linked to this target (Open Targets).
- methylmalonic acidemia with homocystinuria, type cblJ · score 0.80
- Methylmalonic acidemia with homocystinuria · score 0.75
- methylmalonic aciduria and homocystinuria type cblC · score 0.49
- Methylmalonic acidemia with homocystinuria, type cblC · score 0.49
- homocystinuria · score 0.37
- Vitamin B12-responsive methylmalonic acidemia type cblB · score 0.37
- genetic disorder · score 0.19
- head and neck squamous cell carcinoma · score 0.13
- X-linked adrenoleukodystrophy · score 0.05
- vital capacity · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14678-F1 | alphafold | PREDICTED | 86.48 | — |
Amino-acid sequence (606 residues)
MAVAGPAPGA GARPRLDLQF LQRFLQILKV LFPSWSSQNA LMFLTLLCLT LLEQFVIYQV GLIPSQYYGV LGNKDLEGFK TLTFLAVMLI VLNSTLKSFD QFTCNLLYVS WRKDLTEHLH RLYFRGRAYY TLNVLRDDID NPDQRISQDV ERFCRQLSSM ASKLIISPFT LVYYTYQCFQ STGWLGPVSI FGYFILGTVV NKTLMGPIVM KLVHQEKLEG DFRFKHMQIR VNAEPAAFYR AGHVEHMRTD RRLQRLLQTQ RELMSKELWL YIGINTFDYL GSILSYVVIA IPIFSGVYGD LSPAELSTLV SKNAFVCIYL ISCFTQLIDL STTLSDVAGY THRIGQLRET LLDMSLKSQD CEILGESEWG LDTPPGWPAA EPADTAFLLE RVSISAPSSD KPLIKDLSLK ISEGQSLLIT GNTGTGKTSL LRVLGGLWTS TRGSVQMLTD FGPHGVLFLP QKPFFTDGTL REQVIYPLKE VYPDSGSADD ERILRFLELA GLSNLVARTE GLDQQVDWNW YDVLSPGEMQ RLSFARLFYL QPKYAVLDEA TSALTEEVES ELYRIGQQLG MTFISVGHRQ SLEKFHSLVL KLCGGGRWEL MRIKVE
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