Etoposide-induced protein 2.4 homolog (EI24)

About Etoposide-induced protein 2.4 homolog

Etoposide-induced protein 2.4 homolog (EI24) is a protein from Homo sapiens identified by UniProt accession O14681, 340 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	Etoposide-induced protein 2.4 homolog
UniProt accession	O14681
Gene	EI24
Organism	Homo sapiens
Length	340 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
lysosomal storage disease · score 0.37
Intellectual disability · score 0.26
serum alanine aminotransferase measurement · score 0.16
aspartate aminotransferase measurement · score 0.11
FEV/FVC ratio · score 0.10
brain measurement · score 0.09
esophageal squamous cell carcinoma · score 0.08
neoplasm · score 0.07
vital capacity · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14681-F1	alphafold	PREDICTED	86.56	—

Amino-acid sequence (340 residues)

MADSVKTFLQ DLARGIKDSI WGICTISKLD ARIQQKREEQ RRRRASSVLA QRRAQSIERK QESEPRIVSR IFQCCAWNGG VFWFSLLLFY RVFIPVLQSV TARIIGDPSL HGDVWSWLEF FLTSIFSALW VLPLFVLSKV VNAIWFQDIA DLAFEVSGRK PHPFPSVSKI IADMLFNLLL QALFLIQGMF VSLFPIHLVG QLVSLLHMSL LYSLYCFEYR WFNKGIEMHQ RLSNIERNWP YYFGFGLPLA FLTAMQSSYI ISGCLFSILF PLFIISANEA KTPGKAYLFQ LRLFSLVVFL SNRLFHKTVY LQSALSSSTS AEKFPSPHPS PAKLKATAGH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards