Integrin beta-1-binding protein 1 (ITGB1BP1)

About Integrin beta-1-binding protein 1

Integrin beta-1-binding protein 1 (ITGB1BP1) is a protein from Homo sapiens identified by UniProt accession O14713, 200 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.

Target properties

Protein name	Integrin beta-1-binding protein 1
UniProt accession	O14713
Gene	ITGB1BP1
Organism	Homo sapiens
Length	200 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (88)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.42
body height · score 0.09
mean platelet volume · score 0.08
craniometadiaphyseal dysplasia, wormian bone type · score 0.05
progressive spondyloepimetaphyseal dysplasia-short stature-short fourth metatarsals-intellectual disability syndrome · score 0.04
pseudoachondroplasia · score 0.04
Spondyloepiphyseal dysplasia, Nishimura type · score 0.04
Metaphyseal chondrodysplasia, Schmid type · score 0.04
Achondroplasia · score 0.04
spondyloepiphyseal dysplasia tarda · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14713-F1	alphafold	PREDICTED	79.77	—

Amino-acid sequence (200 residues)

MFRKGKKRHS SSSSQSSEIS TKSKSVDSSL GGLSRSSTVA SLDTDSTKSS GQSNNNSDTC AEFRIKYVGA IEKLKLSEGK GLEGPLDLIN YIDVAQQDGK LPFVPPEEEF IMGVSKYGIK VSTSDQYDVL HRHALYLIIR MVCYDDGLGA GKSLLALKTT DASNEEYSLW VYQCNSLEQA QAICKVLSTA FDSVLTSEKP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards