About Tumor necrosis factor receptor superfamily member 10B
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a protein
from Homo sapiens identified by UniProt accession
O14763, 440 residues long.
MolForge cross-references it against 0 known binders and
395 disease associations.
Target properties
| Protein name | Tumor necrosis factor receptor superfamily member 10B |
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| UniProt accession | O14763 |
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| Gene | TNFRSF10B |
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| Organism | Homo sapiens |
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| Length | 440 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (395)
Diseases linked to this target (Open Targets).
- head and neck squamous cell carcinoma · score 0.47
- mean corpuscular volume · score 0.39
- erythrocyte count · score 0.35
- gut microbiome measurement · score 0.34
- mean corpuscular hemoglobin concentration · score 0.34
- serum gamma-glutamyl transferase measurement · score 0.32
- eosinophil count · score 0.32
- blood protein measurement · score 0.31
- serum alanine aminotransferase measurement · score 0.30
- TNF-related apoptosis-inducing ligand receptor 2 measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14763-F1 | alphafold | PREDICTED | 71.17 | — |
Amino-acid sequence (440 residues)
MEQRGQNAPA ASGARKRHGP GPREARGARP GPRVPKTLVL VVAAVLLLVS AESALITQQD LAPQQRAAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KESGTKHSGE VPAVEETVTS SPGTPASPCS LSGIIIGVTV AAVVLIVAVF VCKSLLWKKV LPYLKGICSG GGGDPERVDR SSQRPGAEDN VLNEIVSILQ PTQVPEQEME VQEPAEPTGV NMLSPGESEH LLEPAEAERS QRRRLLVPAN EGDPTETLRQ CFDDFADLVP FDSWEPLMRK LGLMDNEIKV AKAEAAGHRD TLYTMLIKWV NKTGRDASVH TLLDALETLG ERLAKQKIED HLLSSGKFMY LEGNADSAMS
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