Transmembrane 4 L6 family member 5 (TM4SF5)

About Transmembrane 4 L6 family member 5

Transmembrane 4 L6 family member 5 (TM4SF5) is a protein from Homo sapiens identified by UniProt accession O14894, 197 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.

Target properties

Protein name	Transmembrane 4 L6 family member 5
UniProt accession	O14894
Gene	TM4SF5
Organism	Homo sapiens
Length	197 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (68)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.25
coronary artery calcification · score 0.20
sphingolipid measurement · score 0.20
C-X-C motif chemokine 16 measurement · score 0.18
serum gamma-glutamyl transferase measurement · score 0.13
low density lipoprotein cholesterol measurement · score 0.13
triglyceride measurement · score 0.13
pancreatic neoplasm · score 0.09
colon carcinoma · score 0.07
glycogen storage disease due to lactate dehydrogenase H-subunit deficiency · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14894-F1	alphafold	PREDICTED	86.02	—

Amino-acid sequence (197 residues)

MCTGKCARCV GLSLITLCLV CIVANALLLV PNGETSWTNT NHLSLQVWLM GGFIGGGLMV LCPGIAAVRA GGKGCCGAGC CGNRCRMLRS VFSSAFGVLG AIYCLSVSGA GLRNGPRCLM NGEWGYHFED TAGAYLLNRT LWDRCEAPPR VVPWNVTLFS LLVAASCLEI VLCGIQLVNA TIGVFCGDCR KKQDTPH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards