Krueppel-like factor 11 (KLF11)

About Krueppel-like factor 11

Krueppel-like factor 11 (KLF11) is a protein from Homo sapiens identified by UniProt accession O14901, 512 residues long. MolForge cross-references it against 0 known binders and 136 disease associations.

Target properties

Protein name	Krueppel-like factor 11
UniProt accession	O14901
Gene	KLF11
Organism	Homo sapiens
Length	512 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (136)

Diseases linked to this target (Open Targets).

MODY · score 0.58
heel bone mineral density · score 0.43
body height · score 0.42
erythrocyte count · score 0.41
mean corpuscular volume · score 0.39
forced expiratory volume · score 0.39
neuroticism measurement · score 0.38
vital capacity · score 0.36
appendicular lean mass · score 0.35
lean body mass · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14901-F1	alphafold	PREDICTED	48.81	—

Amino-acid sequence (512 residues)

MHTPDFAGPD DARAVDIMDI CESILERKRH DSERSTCSIL EQTDMEAVEA LVCMSSWGQR SQKGDLLRIR PLTPVSDSGD VTTTVHMDAA TPELPKDFHS LSTLCITPPQ SPDLVEPSTR TPVSPQVTDS KACTATDVLQ SSAVVARALS GGAERGLLGL EPVPSSPCRA KGTSVIRHTG ESPAACFPTI QTPDCRLSDS REGEEQLLGH FETLQDTHLT DSLLSTNLVS CQPCLHKSGG LLLTDKGQQA GWPGAVQTCS PKNYENDLPR KTTPLISVSV PAPPVLCQMI PVTGQSSMLP AFLKPPPQLS VGTVRPILAQ AAPAPQPVFV GPAVPQGAVM LVLPQGALPP PAPCAANVMA AGNTKLLPLA PAPVFITSSQ NCVPQVDFSR RRNYVCSFPG CRKTYFKSSH LKAHLRTHTG EKPFNCSWDG CDKKFARSDE LSRHRRTHTG EKKFVCPVCD RRFMRSDHLT KHARRHMTTK KIPGWQAEVG KLNRIASAES PGSPLVSMPA SA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards