About Inhibitor of nuclear factor kappa-B kinase subunit beta
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) is a protein
from Homo sapiens identified by UniProt accession
O14920, 756 residues long.
MolForge cross-references it against 0 known binders and
625 disease associations.
Target properties
| Protein name | Inhibitor of nuclear factor kappa-B kinase subunit beta |
|---|
| UniProt accession | O14920 |
|---|
| Gene | IKBKB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 756 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (625)
Diseases linked to this target (Open Targets).
- severe combined immunodeficiency due to IKK2 deficiency · score 0.77
- COVID-19 · score 0.48
- combined immunodeficiency · score 0.47
- Combined immunodeficiency · score 0.46
- severe combined immunodeficiency · score 0.45
- multiple myeloma · score 0.44
- kidney neoplasm · score 0.37
- skin basal cell carcinoma · score 0.37
- colorectal adenocarcinoma · score 0.37
- neuroinflammatory disorder · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14920-F1 | alphafold | PREDICTED | 86.54 | — |
Amino-acid sequence (756 residues)
MSWSPSLTTQ TCGAWEMKER LGTGGFGNVI RWHNQETGEQ IAIKQCRQEL SPRNRERWCL EIQIMRRLTH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ GGDLRKYLNQ FENCCGLREG AILTLLSDIA SALRYLHENR IIHRDLKPEN IVLQQGEQRL IHKIIDLGYA KELDQGSLCT SFVGTLQYLA PELLEQQKYT VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE VDIVVSEDLN GTVKFSSSLP YPNNLNSVLA ERLEKWLQLM LMWHPRQRGT DPTYGPNGCF KALDDILNLK LVHILNMVTG TIHTYPVTED ESLQSLKARI QQDTGIPEED QELLQEAGLA LIPDKPATQC ISDGKLNEGH TLDMDLVFLF DNSKITYETQ ISPRPQPESV SCILQEPKRN LAFFQLRKVW GQVWHSIQTL KEDCNRLQQG QRAAMMNLLR NNSCLSKMKN SMASMSQQLK AKLDFFKTSI QIDLEKYSEQ TEFGITSDKL LLAWREMEQA VELCGRENEV KLLVERMMAL QTDIVDLQRS PMGRKQGGTL DDLEEQAREL YRRLREKPRD QRTEGDSQEM VRLLLQAIQS FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE KTVVRLQEKR QKELWNLLKI ACSKVRGPVS GSPDSMNASR LSQPGQLMSQ PSTASNSLPE PAKKSEELVA EAHNLCTLLE NAIQDTVREQ DQSFTALDWS WLQTEEEEHS CLEQAS
Explore Inhibitor of nuclear factor kappa-B kinase subunit beta with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets