About Vacuolar protein sorting-associated protein 26C
Vacuolar protein sorting-associated protein 26C (VPS26C) is a protein
from Homo sapiens identified by UniProt accession
O14972, 297 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Vacuolar protein sorting-associated protein 26C |
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| UniProt accession | O14972 |
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| Gene | VPS26C |
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| Organism | Homo sapiens |
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| Length | 297 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (71)
Diseases linked to this target (Open Targets).
- gut microbiome measurement · score 0.16
- Griscelli syndrome type 3 · score 0.05
- Fuchs endothelial corneal dystrophy · score 0.05
- piebald trait-neurologic defects syndrome · score 0.04
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.04
- corneal-cerebellar syndrome · score 0.04
- Tietz syndrome · score 0.04
- Woolly hair · score 0.04
- uncombable hair syndrome · score 0.04
- oculocutaneous albinism type 3 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14972-F1 | alphafold | PREDICTED | 92.89 | — |
Amino-acid sequence (297 residues)
MGTALDIKIK RANKVYHAGE VLSGVVVISS KDSVQHQGVS LTMEGTVNLQ LSAKSVGVFE AFYNSVKPIQ IINSTIEMVK PGKFPSGKTE IPFEFPLHLK GNKVLYETYH GVFVNIQYTL RCDMKRSLLA KDLTKTCEFI VHSAPQKGKF TPSPVDFTIT PETLQNVKER ALLPKFLLRG HLNSTNCVIT QPLTGELVVE SSEAAIRSVE LQLVRVETCG CAEGYARDAT EIQNIQIADG DVCRGLSVPI YMVFPRLFTC PTLETTNFKV EFEVNIVVLL HPDHLITENF PLKLCRI
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