U6 snRNA-associated Sm-like protein LSm1 (LSM1)

About U6 snRNA-associated Sm-like protein LSm1

U6 snRNA-associated Sm-like protein LSm1 (LSM1) is a protein from Homo sapiens identified by UniProt accession O15116, 133 residues long. MolForge cross-references it against 0 known binders and 127 disease associations.

Target properties

Protein name	U6 snRNA-associated Sm-like protein LSm1
UniProt accession	O15116
Gene	LSM1
Organism	Homo sapiens
Length	133 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (127)

Diseases linked to this target (Open Targets).

Global developmental delay · score 0.26
schizophrenia · score 0.14
systolic blood pressure · score 0.14
urate measurement · score 0.12
oligohydramnios · score 0.12
Hydroureter · score 0.12
cryptorchidism · score 0.12
Strabismus · score 0.12
Inguinal hernia · score 0.12
Intellectual disability · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15116-F1	alphafold	PREDICTED	89.71	—

Amino-acid sequence (133 residues)

MNYMPGTASL IEDIDKKHLV LLRDGRTLIG FLRSIDQFAN LVLHQTVERI HVGKKYGDIP RGIFVVRGEN VVLLGEIDLE KESDTPLQQV SIEEILEEQR VEQQTKLEAE KLKVQALKDR GLSIPRADTL DEY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards