Surfeit locus protein 4 (SURF4)

About Surfeit locus protein 4

Surfeit locus protein 4 (SURF4) is a protein from Homo sapiens identified by UniProt accession O15260, 269 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.

Target properties

Protein name	Surfeit locus protein 4
UniProt accession	O15260
Gene	SURF4
Organism	Homo sapiens
Length	269 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (76)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
total cholesterol measurement · score 0.22
apolipoprotein A 1 measurement · score 0.18
gut microbiome measurement · score 0.18
low density lipoprotein cholesterol measurement · score 0.16
apolipoprotein B measurement · score 0.16
platelet endothelial cell adhesion molecule measurement · score 0.16
heel bone mineral density · score 0.15
vital capacity · score 0.13
hemoglobin measurement · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15260-F1	alphafold	PREDICTED	84.62	—

Amino-acid sequence (269 residues)

MGQNDLMGTA EDFADQFLRV TKQYLPHVAR LCLISTFLED GIRMWFQWSE QRDYIDTTWN CGYLLASSFV FLNLLGQLTG CVLVLSRNFV QYACFGLFGI IALQTIAYSI LWDLKFLMRN LALGGGLLLL LAESRSEGKS MFAGVPTMRE SSPKQYMQLG GRVLLVLMFM TLLHFDASFF SIVQNIVGTA LMILVAIGFK TKLAALTLVV WLFAINVYFN AFWTIPVYKP MHDFLKYDFF QTMSVIGGLL LVVALGPGGV SMDEKKKEW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards