About Serine palmitoyltransferase 1
Serine palmitoyltransferase 1 (SPTLC1) is a protein
from Homo sapiens identified by UniProt accession
O15269, 473 residues long.
MolForge cross-references it against 0 known binders and
127 disease associations.
Target properties
| Protein name | Serine palmitoyltransferase 1 |
|---|
| UniProt accession | O15269 |
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| Gene | SPTLC1 |
|---|
| Organism | Homo sapiens |
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| Length | 473 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (127)
Diseases linked to this target (Open Targets).
- hereditary sensory and autonomic neuropathy type 1 · score 0.64
- Charcot-Marie-Tooth disease · score 0.58
- Familial dysautonomia · score 0.46
- genetic disorder · score 0.45
- juvenile amyotrophic lateral sclerosis · score 0.38
- neurodegenerative disease · score 0.35
- Sensorimotor neuropathy · score 0.33
- sphingomyelin measurement · score 0.31
- amyotrophic lateral sclerosis · score 0.30
- Muscle spasm · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15269-F1 | alphafold | PREDICTED | 94.14 | — |
Amino-acid sequence (473 residues)
MATATEQWVL VEMVQALYEA PAYHLILEGI LILWIIRLLF SKTYKLQERS DLTVKEKEEL IEEWQPEPLV PPVPKDHPAL NYNIVSGPPS HKTVVNGKEC INFASFNFLG LLDNPRVKAA ALASLKKYGV GTCGPRGFYG TFDVHLDLED RLAKFMKTEE AIIYSYGFAT IASAIPAYSK RGDIVFVDRA ACFAIQKGLQ ASRSDIKLFK HNDMADLERL LKEQEIEDQK NPRKARVTRR FIVVEGLYMN TGTICPLPEL VKLKYKYKAR IFLEESLSFG VLGEHGRGVT EHYGINIDDI DLISANMENA LASIGGFCCG RSFVIDHQRL SGQGYCFSAS LPPLLAAAAI EALNIMEENP GIFAVLKEKC GQIHKALQGI SGLKVVGESL SPAFHLQLEE STGSREQDVR LLQEIVDQCM NRSIALTQAR YLEKEEKCLP PPSIRVVVTV EQTEEELERA ASTIKEVAQA VLL
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