About Serine palmitoyltransferase 2
Serine palmitoyltransferase 2 (SPTLC2) is a protein
from Homo sapiens identified by UniProt accession
O15270, 562 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Serine palmitoyltransferase 2 |
|---|
| UniProt accession | O15270 |
|---|
| Gene | SPTLC2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 562 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (92)
Diseases linked to this target (Open Targets).
- hereditary sensory and autonomic neuropathy type 1 · score 0.67
- neurodegenerative disease · score 0.56
- Charcot-Marie-Tooth disease · score 0.49
- Familial dysautonomia · score 0.46
- Red cell distribution width · score 0.45
- Amyotrophic lateral sclerosis · score 0.37
- multiple sclerosis · score 0.37
- neuroinflammatory disorder · score 0.37
- Alzheimer disease · score 0.37
- lysosomal storage disease · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15270-F1 | alphafold | PREDICTED | 86.22 | — |
Amino-acid sequence (562 residues)
MRPEPGGCCC RRTVRANGCV ANGEVRNGYV RSSAAAAAAA AAGQIHHVTQ NGGLYKRPFN EAFEETPMLV AVLTYVGYGV LTLFGYLRDF LRYWRIEKCH HATEREEQKD FVSLYQDFEN FYTRNLYMRI RDNWNRPICS VPGARVDIME RQSHDYNWSF KYTGNIIKGV INMGSYNYLG FARNTGSCQE AAAKVLEEYG AGVCSTRQEI GNLDKHEELE ELVARFLGVE AAMAYGMGFA TNSMNIPALV GKGCLILSDE LNHASLVLGA RLSGATIRIF KHNNMQSLEK LLKDAIVYGQ PRTRRPWKKI LILVEGIYSM EGSIVRLPEV IALKKKYKAY LYLDEAHSIG ALGPTGRGVV EYFGLDPEDV DVMMGTFTKS FGASGGYIGG KKELIDYLRT HSHSAVYATS LSPPVVEQII TSMKCIMGQD GTSLGKECVQ QLAENTRYFR RRLKEMGFII YGNEDSPVVP LMLYMPAKIG AFGREMLKRN IGVVVVGFPA TPIIESRARF CLSAAHTKEI LDTALKEIDE VGDLLQLKYS RHRLVPLLDR PFDETTYEET ED
Explore Serine palmitoyltransferase 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets