About Trinucleotide repeat-containing gene 18 protein
Trinucleotide repeat-containing gene 18 protein (TNRC18) is a protein
from Homo sapiens identified by UniProt accession
O15417, 2968 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Trinucleotide repeat-containing gene 18 protein |
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| UniProt accession | O15417 |
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| Gene | TNRC18 |
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| Organism | Homo sapiens |
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| Length | 2968 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (46)
Diseases linked to this target (Open Targets).
- Crohn's disease · score 0.39
- ulcerative colitis · score 0.39
- neurodegenerative disease · score 0.37
- psoriatic arthritis · score 0.35
- inflammatory bowel disease · score 0.34
- ulcerative proctosigmoiditis · score 0.32
- Iridocyclitis · score 0.32
- ulcer disease · score 0.31
- type 1 diabetes mellitus · score 0.30
- ankylosing spondylitis · score 0.29
3D Structure (9)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Amino-acid sequence (2968 residues)
MDGRDFGPQR SVHGPPPPLL SGLAMDSHRV GAATAGRLPA SGLPGPLPPG KYMAGLNLHP HPGEAFLGSF VASGMGPSAS SHGSPVPLPS DLSFRSPTPS NLPMVQLWAA HAHEGFSHLP SGLYPSYLHL NHLEPPSSGS PLLSQLGQPS IFDTQKGQGP GGDGFYLPTA GAPGSLHSHA PSARTPGGGH SSGAPAKGSS SRDGPAKERA GRGGEPPPLF GKKDPRARGE EASGPRGVVD LTQEARAEGR QDRGPPRLAE RLSPFLAESK TKNAALQPSV LTMCNGGAGD VGLPALVAEA GRGGAKEAAR QDEGARLLRR TETLLPGPRP CPSPLPPPPA PPKGPPAPPA ATPAGVYTVF REQGREHRVV APTFVPSVEA FDERPGPIQI ASQARDARAR EREAGRPGVL QAPPGSPRPL DRPEGLREKN SVIRSLKRPP PADAPTVRAT RASPDPRAYV PAKELLKPEA DPRPCERAPR GPAGPAAQQA AKLFGLEPGR PPPTGPEHKW KPFELGNFAA TQMAVLAAQH HHSRAEEEAA VVAASSSKKA YLDPGAVLPR SAATCGRPVA DMHSAAHGSG EASAMQSLIK YSGSFARDAV AVRPGGCGKK SPFGGLGTMK PEPAPTSAGA SRAQARLPHS GGPAAGGGRQ LKRDPERPES AKAFGREGSG AQGEAEVRHP PVGIAVAVAR QKDSGGSGRL GPGLVDQERS LSLSNVKGHG RADEDCVDDR ARHREERLLG ARLDRDQEKL LRESKELADL ARLHPTSCAP NGLNPNLMVT GGPALAGSGR WSADPAAHLA THPWLPRSGN ASMWLAGHPY GLGPPSLHQG MAPAFPPGLG GSLPSAYQFV RDPQSGQLVV IPSDHLPHFA ELMERATVPP LWPALYPPGR SPLHHAQQLQ LFSQQHFLRQ QEFLYLQQQA AQALELQRSA QLVQERLKAQ EHRAEMEEKG SKRGLEAAGK AGLATAGPGL LPRKPPGLAA GPAGTYGKAV SPPPSPRASP VAALKAKVIQ KLEDVSKPPA YAYPATPSSH PTSPPPASPP PTPGITRKEE APENVVEKKD LELEKEAPSP FQALFSDIPP RYPFQALPPH YGRPYPFLLQ PTAAADADGL APDVPLPADG PERLALSPED KPIRLSPSKI TEPLREGPEE EPLAEREVKA EVEDMDEGPT ELPPLESPLP LPAAEAMATP SPAGGCGGGL LEAQALSATG QSCAEPSECP DFVEGPEPRV DSPGRTEPCT AALDLGVQLT PETLVEAKEE PVEVPVAVPV VEAVPEEGLA QVAPSESQPT LEMSDCDVPA GEGQCPSLEP QEAVPVLGST CFLEEASSDQ FLPSLEDPLA GMNALAAAAE LPQARPLPSP GAAGAQALEK LEAAESLVLE QSFLHGITLL SEIAELELER RSQEMGGAER ALVARPSLES LLAAGSHMLR EVLDGPVVDP LKNLRLPREL KPNKKYSWMR KKEERMYAMK SSLEDMDALE LDFRMRLAEV QRQYKEKQRE LVKLQRRRDS EDRREEPHRS LARRGPGRPR KRTHAPSALS PPRKRGKSGH SSGKLSSKSL LTSDDYELGA GIRKRHKGSE EEHDALIGMG KARGRNQTWD EHEASSDFIS QLKIKKKKMA SDQEQLASKL DKALSLTKQD KLKSPFKFSD SAGGKSKTSG GCGRYLTPYD SLLGKNRKAL AKGLGLSLKS SREGKHKRAA KTRKMEVGFK ARGQPKSAHS PFASEVSSYS YNTDSEEDEE FLKDEWPAQG PSSSKLTPSL LCSMVAKNSK AAGGPKLTKR GLAAPRTLKP KPATSRKQPF CLLLREAEAR SSFSDSSEES FDQDESSEEE DEEEELEEED EASGGGYRLG ARERALSPGL EESGLGLLAR FAASALPSPT VGPSLSVVQL EAKQKARKKE ERQSLLGTEF EYTDSESEVK VRKRSPAGLL RPKKGLGEPG PSLAAPTPGA RGPDPSSPDK AKLAVEKGRK ARKLRGPKEP GFEAGPEASD DDLWTRRRSE RIFLHDASAA APAPVSTAPA TKTSRCAKGG PLSPRKDAGR AKDRKDPRKK KKGKEAGPGA GLPPPRAPAL PSEARAPHAS SLTAAKRSKA KAKGKEVKKE NRGKGGAVSK LMESMAAEED FEPNQDSSFS EDEHLPRGGA VERPLTPAPR SCIIDKDELK DGLRVLIPMD DKLLYAGHVQ TVHSPDIYRV VVEGERGNRP HIYCLEQLLQ EAIIDVRPAS TRFLPQGTRI AAYWSQQYRC LYPGTVVRGL LDLEDDGDLI TVEFDDGDTG RIPLSHIRLL PPDYKIQCAE PSPALLVPSA KRRSRKTSKD TGEGKDGGTA GSEEPGAKAR GRGRKPSAKA KGDRAATLEE GNPTDEVPST PLALEPSSTP GSKKSPPEPV DKRAKAPKAR PAPPQPSPAP PAFTSCPAPE PFAELPAPAT SLAPAPLITM PATRPKPKKA RAAEESGAKG PRRPGEEAEL LVKLDHEGVT SPKSKKAKEA LLLREDPGAG GWQEPKSLLS LGSYPPAAGS SEPKAPWPKA TDGDLAQEPG PGLTFEDSGN PKSPDKAQAE QDGAEESESS SSSSSGSSSS SSSSSSSGSE TEGEEEGDKN GDGGCGTGGR NCSAASSRAA SPASSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS STTDEDSSCS SDDEAAPAPT AGPSAQAALP TKATKQAGKA RPSAHSPGKK TPAPQPQAPP PQPTQPLQPK AQAGAKSRPK KREGVHLPTT KELAKRQRLP SVENRPKIAA FLPARQLWKW FGKPTQRRGM KGKARKLFYK AIVRGKEMIR IGDCAVFLSA GRPNLPYIGR IQSMWESWGN NMVVRVKWFY HPEETSPGKQ FHQGQHWDQK SSRSLPAALR VSSQRKDFME RALYQSSHVD ENDVQTVSHK CLVVGLEQYE QMLKTKKYQD SEGLYYLAGT YEPTTGMIFS TDGVPVLC
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