Alpha-2,8-sialyltransferase 8E (ST8SIA5)

About Alpha-2,8-sialyltransferase 8E

Alpha-2,8-sialyltransferase 8E (ST8SIA5) is a protein from Homo sapiens identified by UniProt accession O15466, 376 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Alpha-2,8-sialyltransferase 8E
UniProt accession	O15466
Gene	ST8SIA5
Organism	Homo sapiens
Length	376 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

PHF-tau measurement · score 0.32
neuroticism measurement · score 0.18
depressive symptom measurement · score 0.18
wellbeing measurement · score 0.17
creatinine measurement · score 0.05
mean corpuscular volume · score 0.03
Red cell distribution width · score 0.03
drug use measurement · score 0.02
age-related hearing impairment · score 0.02
mean corpuscular hemoglobin concentration · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15466-F1	alphafold	PREDICTED	90.79	—

Amino-acid sequence (376 residues)

MRYADPSANR DLLGSRTLLF IFICAFALVT LLQQILYGRN YIKRYFEFYE GPFEYNSTRC LELRHEILEV KVLSMVKQSE LFDRWKSLQM CKWAMNISEA NQFKSTLSRC CNAPAFLFTT QKNTPLGTKL KYEVDTSGIY HINQEIFRMF PKDMPYYRSQ FKKCAVVGNG GILKNSRCGR EINSADFVFR CNLPPISEKY TMDVGVKTDV VTVNPSIITE RFHKLEKWRR PFYRVLQVYE NASVLLPAFY NTRNTDVSIR VKYVLDDFES PQAVYYFHPQ YLVNVSRYWL SLGVRAKRIS TGLILVTAAL ELCEEVHLFG FWAFPMNPSG LYITHHYYDN VKPRPGFHAM PSEIFNFLHL HSRGILRVHT GTCSCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards