About Synaptobrevin homolog YKT6
Synaptobrevin homolog YKT6 (YKT6) is a protein
from Homo sapiens identified by UniProt accession
O15498, 198 residues long.
MolForge cross-references it against 0 known binders and
88 disease associations.
Target properties
| Protein name | Synaptobrevin homolog YKT6 |
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| UniProt accession | O15498 |
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| Gene | YKT6 |
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| Organism | Homo sapiens |
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| Length | 198 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (88)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- birth weight · score 0.39
- HbA1c measurement · score 0.34
- fasting blood glucose measurement · score 0.30
- alkaline phosphatase measurement · score 0.29
- type 2 diabetes mellitus · score 0.28
- glucose measurement · score 0.27
- hemoglobin A1 measurement · score 0.24
- serum metabolite measurement · score 0.24
- BMI-adjusted fasting blood glucose measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15498-F1 | alphafold | PREDICTED | 90.91 | — |
Amino-acid sequence (198 residues)
MKLYSLSVLY KGEAKVVLLK AAYDVSSFSF FQRSSVQEFM TFTSQLIVER SSKGTRASVK EQDYLCHVYV RNDSLAGVVI ADNEYPSRVA FTLLEKVLDE FSKQVDRIDW PVGSPATIHY PALDGHLSRY QNPREADPMT KVQAELDETK IILHNTMESL LERGEKLDDL VSKSEVLGTQ SKAFYKTARK QNSCCAIM
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