About 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1) is a protein
from Homo sapiens identified by UniProt accession
O15528, 508 residues long.
MolForge cross-references it against 0 known binders and
490 disease associations.
Target properties
| Protein name | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
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| UniProt accession | O15528 |
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| Gene | CYP27B1 |
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| Organism | Homo sapiens |
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| Length | 508 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (490)
Diseases linked to this target (Open Targets).
- vitamin D-dependent rickets, type 1A · score 0.81
- Hypocalcemic vitamin D-dependent rickets · score 0.72
- vitamin D-dependent rickets, type 1 · score 0.52
- genetic disorder · score 0.41
- rickets · score 0.37
- head and neck squamous cell carcinoma · score 0.23
- lung adenocarcinoma · score 0.23
- vitamin D measurement · score 0.21
- glioblastoma multiforme · score 0.19
- alkaline phosphatase measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15528-F1 | alphafold | PREDICTED | 86.79 | — |
Amino-acid sequence (508 residues)
MTQTLKYASR VFHRVRWAPE LGASLGYREY HSARRSLADI PGPSTPSFLA ELFCKGGLSR LHELQVQGAA HFGPVWLASF GTVRTVYVAA PALVEELLRQ EGPRPERCSF SPWTEHRRCR QRACGLLTAE GEEWQRLRSL LAPLLLRPQA AARYAGTLNN VVCDLVRRLR RQRGRGTGPP ALVRDVAGEF YKFGLEGIAA VLLGSRLGCL EAQVPPDTET FIRAVGSVFV STLLTMAMPH WLRHLVPGPW GRLCRDWDQM FAFAQRHVER REAEAAMRNG GQPEKDLESG AHLTHFLFRE ELPAQSILGN VTELLLAGVD TVSNTLSWAL YELSRHPEVQ TALHSEITAA LSPGSSAYPS ATVLSQLPLL KAVVKEVLRL YPVVPGNSRV PDKDIHVGDY IIPKNTLVTL CHYATSRDPA QFPEPNSFRP ARWLGEGPTP HPFASLPFGF GKRSCMGRRL AELELQMALA QILTHFEVQP EPGAAPVRPK TRTVLVPERS INLQFLDR
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