Calcitriol

Vitamin D3 Analog — ALIMENTARY TRACT AND METABOLISM

Key facts

Calcitriol is an ofp drug in the Vitamin D3 Analog class catalogued in DrugCentral. It was first approved by the FDA in 1978. DrugCentral lists 10 molecular targets, including VDR, Vdr and VDR. Recorded indications include Hyperparathyroidism Secondary to Chronic Renal Failure, Hypocalcemia, Hypocalcemia from End-Stage Renal Disease with Dialysis and Hypoparathyroidism.

• Approval status: ofp (first approved 1978 by the FDA).
• Drug class: Vitamin D3 Analog.
• Molecular targets: VDR, Vdr, VDR and VDR (10 listed in DrugCentral).
• Indications: Hyperparathyroidism Secondary to Chronic Renal Failure, Hypocalcemia, Hypocalcemia from End-Stage Renal Disease with Dialysis, Hypoparathyroidism and Hypophosphatemia and others.
• ATC code: A11CC04 (Vitamin D and analogues).
• Molecular formula: C27H44O3; molecular weight 416.65 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (7)

• Hyperparathyroidism Secondary to Chronic Renal Failure
• Hypocalcemia
• Hypocalcemia from End-Stage Renal Disease with Dialysis
• Hypoparathyroidism
• Hypophosphatemia
• Plaque psoriasis
• Renal osteodystrophy

Off-label uses (5)

• Familial x-linked hypophosphatemic vitamin D refractory rickets
• Neonatal hypocalcemic tetany
• Rickets
• Vitamin D deficiency
• Vitamin D Dependent Rickets

Contraindications (8)

• Arteriosclerosis obliterans
• Hypercalcemia
• Hypercalcemia associated with Sarcoidosis
• Hyperphosphatemia
• Hypervitaminosis D
• Kidney disease
• Kidney stone
• Sarcoidosis

Mechanism & targets

• Established pharmacologic class: Vitamin D3 Analog

Molecular targets (10)

Target	Gene	Action	Activity
Vitamin D3 receptor	VDR	unknown	Ki 10.60
Vitamin D3 receptor	Vdr	unknown	Ki 10.30
Vitamin D3 receptor	VDR	unknown	EC50 10.30
Vitamin D3 receptor	VDR	unknown	Kd 10.15
Vitamin D3 receptor	VDR	agonist	EC50 8.40
Vitamin D3 receptor A	vdra	unknown	EC50 8.26
Vitamin D-binding protein	GC	unknown	Kd 7.62
Vitamin D3 receptor	Vdr	unknown	EC50 7.00
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	unknown	—
Vitamin D 25-hydroxylase	CYP2R1	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1978-08-17	FDA	—	VALIDUS PHARMS

ATC classification

ATC code	Therapeutic hierarchy
A11CC04	ALIMENTARY TRACT AND METABOLISM › VITAMINS › VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO › Vitamin D and analogues
D05AX03	DERMATOLOGICALS › ANTIPSORIATICS › ANTIPSORIATICS FOR TOPICAL USE › Other antipsoriatics for topical use

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Recalled product	1333.7
Hypercalcaemia	836.0
Hypocalcaemia	784.6
Appendicolith	631.5
Appendicitis	494.8
Blood phosphorus increased	490.8
Milk-alkali syndrome	464.4
Peritonitis bacterial	394.7
Hyperphosphataemia	371.6
Cardiogenic shock	361.1
Drug hypersensitivity	355.1
Calciphylaxis	295.4

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Calcitriol is on its molecule page.

• Molecular formula: C₂₇H₄₄O₃
• Molecular weight: 416.65 g/mol
• CAS number: 32222-06-3
• InChIKey: GMRQFYUYWCNGIN-NKMMMXOESA-N
• PubChem CID: 5280453

C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Calcitriol used for?

DrugCentral lists the following indications for Calcitriol: Hyperparathyroidism Secondary to Chronic Renal Failure, Hypocalcemia, Hypocalcemia from End-Stage Renal Disease with Dialysis, Hypoparathyroidism, Hypophosphatemia, Plaque psoriasis and Renal osteodystrophy.

How does Calcitriol work?

Its molecular targets in DrugCentral include VDR, Vdr, VDR and VDR.

When was Calcitriol first approved?

Calcitriol was first approved by the FDA in 1978.

What drug class does Calcitriol belong to?

Calcitriol is in the Vitamin D3 Analog class.

What is the chemical formula of Calcitriol?

Calcitriol has the molecular formula C27H44O3 and a molecular weight of 416.65 g/mol.

Sources

• DrugCentral drug card 466 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL846 — compound record and bioactivity
• PubChem CID 5280453 — chemical identifiers
• DrugBank DB00136 — drug record
• FDA UNII FXC9231JVH — substance identity
• DailyMed: FDA labels for Calcitriol — current prescribing information (label search)
• UniProt P11473 (VDR) — target protein
• UniProt P02774 (GC) — target protein
• UniProt O15528 (CYP27B1) — target protein
• UniProt Q6VVX0 (CYP2R1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.